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antithrombin London

has deletion of P1 arginine

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Serpins: 906
    - Antithrombin Proteins: 6
      - antithrombin London: 1
- Peptides: 82426
  - Serpins: 906
    - Antithrombin Proteins: 6
      - antithrombin London: 1

Experts

1.	Chhablani, Neetu: 1 article (04/2003)
2.	Laffan, Mike: 1 article (04/2003)
3.	Lane, David A: 1 article (04/2003)
4.	Olson, Steven T: 1 article (04/2003)
5.	Raja, Srikumar M: 1 article (04/2003)
6.	Swanson, Richard: 1 article (04/2003)
7.	Thompson, Elizabeth: 1 article (04/2003)

Related Diseases

1.

Thrombosis (Thrombus)

04/18/2003 - "The unusually severe thrombosis associated with the heterozygous mutation may be explained by the ability of antithrombin London to bind endogenous heparan sulfate or heparin molecules with high affinity and to thereby block activation of the normal inhibitor."
04/18/2003 - "Deletion of P1 arginine in a novel antithrombin variant (antithrombin London) abolishes inhibitory activity but enhances heparin affinity and is associated with early onset thrombosis."

Related Drugs and Biologics

1.	Heparitin Sulfate (Heparan Sulfate)
2.	Heparin (Liquaemin)
3.	Arginine (L-Arginine)
4.	Antithrombins