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human glutamate carboxypeptidase II

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highly expressed in prostate epithelium, used as diagnostic tool, see also PROSTATE-SPECIFIC ANTIGEN; RefSeq NM_004476

Also Known As:

glutamate carboxypeptidase II, human; PSM antigen; folate hydrolase (prostate-specific membrane antigen) 1, human; prostate-specific membrane antigen; prostate-specific membrane antigen, human

Networked: 578 relevant articles (21 outcomes, 62 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bander, Neil H: 35 articles (01/2016 - 04/2003)
2.	Pomper, Martin G: 22 articles (01/2016 - 06/2005)
3.	Berkman, Clifford E: 22 articles (10/2015 - 10/2006)
4.	Mease, Ronnie C: 17 articles (09/2015 - 06/2005)
5.	Liu, Tiancheng: 17 articles (05/2014 - 10/2006)
6.	Goldsmith, Stanley J: 16 articles (01/2016 - 04/2003)
7.	Nanus, David M: 15 articles (01/2016 - 10/2003)
8.	Vallabhajosula, Shankar: 13 articles (01/2016 - 04/2003)
9.	Wu, Lisa Y: 13 articles (05/2014 - 01/2008)
10.	Heston, Warren D W: 12 articles (11/2014 - 01/2002)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 08/01/2015 - "Recently, a (68)Gallium-labeled ligand of the prostate-specific membrane antigen ((68)Ga-PSMA) has been introduced in PET-imaging of prostate cancer with first promising results. " 05/01/2008 - "Improved effects of a double suicide gene system on prostate cancer cells by targeted regulation of prostate-specific membrane antigen promoter and enhancer." 05/01/1995 - "Of 20 metastatic prostate cancer patients 16 (80%) had positive polymerase chain reactions for PSA, while only 10 (50%) had positive results for prostate specific membrane antigen. " 12/01/2015 - "This study will provide benchmark data for comparing performance of proposed prostate-specific membrane antigen (PSMA) targeting agents for prostate cancer. " 06/01/2015 - "The aim of the study was to evaluate the diagnostic value of the prostate-specific membrane antigen (PSMA) ligand (68)Ga-HBED-CC (PSMA PET/CT) in patients with prostate cancer and evaluate the value of early imaging of the pelvis. "
2.	Neoplasms (Cancer) 01/01/2013 - "Therefore, the aim of the present study was to generate prostate-specific membrane antigen (PSMA)×CD3 diabodies as a novel treatment option for this tumor. " 03/14/2012 - "Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control nontargeted probes. " 09/01/2012 - "Previous studies have demonstrated that the expression of prostate-specific membrane antigen (PSMA) is restricted to endothelium from tumor-associated neovasculature. " 01/01/2012 - "Human prostate tumor vaccine and gene therapy trials using ex vivo methods to prime dendritic cells (DCs) with prostate specific membrane antigen (PSMA) have been somewhat successful, but to date the lengthy ex vivo manipulation of DCs has limited the widespread clinical utility of this approach. " 07/28/2010 - "In the present study, we used replication deficient adenoviruses to introduce a tumor-associated Ag (a truncated human prostate-specific membrane antigen (tPSMA)) and the T cell costimulatory molecule 4-1BBL into murine DCs, and observed the ability of these recombinant DCs to elicit tPSMA-directed T-cell responses in vitro and anti-tumor immunity to RM-1-tPSMA in a murine tumor model. "
3.	Neoplasm Metastasis (Metastasis) 12/01/2015 - "Prostate specific membrane antigen (PSMA) is one attractive target for diagnosis and therapy of metastasized PCa since its expression levels are directly correlated to androgen independence, metastasis, and progression. " 05/01/2014 - "It has recently been reported that metastases of prostate cancer usually show highly heterogeneous or partly lost prostate-specific membrane antigen (PSMA) expression. " 08/01/2012 - "Reports remain insufficient on whether and how prostate-specific membrane antigen (PSMA) can influence in vivo osseous metastasis of prostate cancer (PCa). " 08/01/2012 - "Prostate-specific membrane antigen can promote in vivo osseous metastasis of prostate cancer cells in mice." 12/01/2009 - "Furthermore, the neovasculatures of 16 (84%) of 19 liver and 4 (80%) of 5 nodal metastases from colorectal carcinomas were prostate-specific membrane antigen positive. "
4.	Carcinoma (Carcinomatosis) 12/01/2015 - "Prostate-specific membrane antigen (PSMA) is a promising target for diagnostics and therapy of prostate carcinoma (PCa). " 07/01/2014 - "Recently, prostate-specific membrane antigen (PSMA) has been shown to be a promising marker for the identification of metastatic prostate carcinoma in surgical specimens. " 05/01/2014 - "Biochemical characterization of prostate-specific membrane antigen from canine prostate carcinoma cells." 11/01/2013 - "Detection and localization of carcinoma within the prostate using high resolution transrectal gamma imaging (TRGI) of monoclonal antibody directed at prostate specific membrane antigen (PSMA)--proof of concept and initial imaging results." 04/01/2013 - "Prostate-specific membrane antigen (PSMA) is a cell surface protein with high expression in prostate carcinoma (PC) cells. "
5.	Adenocarcinoma 03/01/2007 - "Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray technique." 07/01/2013 - "Prostate specific membrane antigen (PSMA) is primarily expressed in glandular prostatic tissue and is frequently utilized to detect primary or metastatic prostatic adenocarcinoma (CaP). " 01/01/2011 - "Prostate specific membrane antigen (PSMA) is overexpressed in prostatic adenocarcinoma (CaP), and its expression is negatively regulated by androgen stimulation. " 06/01/2009 - "Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is overexpressed in advanced stage prostate adenocarcinomas. " 03/01/2008 - "Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma."

Related Drugs and Biologics

1.	Antigens
2.	Prostate-Specific Antigen (Semenogelase)
3.	monoclonal antibody J591
4.	DNA (Deoxyribonucleic Acid)
5.	Antibodies
6.	Capromab Pendetide
7.	Micelles
8.	Vaccines
9.	phosphoramidic acid
10.	tributyltin

Related Therapies and Procedures

1.	Immunotherapy
2.	Castration
3.	Radioimmunotherapy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Prostatectomy (Retropubic Prostatectomy)