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dihydroceramide synthase

catalyzes the conversion of dihydroceramide to ceramide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - dihydroceramide synthase: 1

Experts

1.	Akiyama, Takeshi: 1 article (05/2003)
2.	Hosoda, Yoshiko: 1 article (05/2003)
3.	Koyanagi, Satoru: 1 article (05/2003)
4.	Kuga, Minoru: 1 article (05/2003)
5.	Shibuya, Shiroshi: 1 article (05/2003)
6.	Shimeno, Hiroshi: 1 article (05/2003)
7.	Soeda, Shinji: 1 article (05/2003)
8.	Takechi, Hiroaki: 1 article (05/2003)
9.	Yokomatsu, Tsutomu: 1 article (05/2003)

Related Diseases

1.	Sarcoma 180 05/20/2003 - "However, gel filtration of the enzyme solubilized from the Sarcoma 180 tumor masses demonstrated that its molecular weight was 1300 kDa. These results suggest that malignant transformation causes the cell to produce a form of dihydroceramide synthase with a larger than normal molecular mass; the increased molecular mass may account for the enzyme's increased catalytic efficiency." 05/20/2003 - "To investigate the characteristics of dihydroceramide synthase, we prepared microsomes from Sarcoma 180 tumor masses and healthy mouse liver cells, and compared their catalytic activities on dihydroceramide formation. "
2.	Neoplasms (Cancer) 05/20/2003 - "Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase." 05/20/2003 - "However, gel filtration of the enzyme solubilized from the Sarcoma 180 tumor masses demonstrated that its molecular weight was 1300 kDa. These results suggest that malignant transformation causes the cell to produce a form of dihydroceramide synthase with a larger than normal molecular mass; the increased molecular mass may account for the enzyme's increased catalytic efficiency." 05/20/2003 - "To investigate the characteristics of dihydroceramide synthase, we prepared microsomes from Sarcoma 180 tumor masses and healthy mouse liver cells, and compared their catalytic activities on dihydroceramide formation. " 05/20/2003 - "The high levels were significantly reduced by a single administration of the dihydroceramide synthase inhibitor fumonisin B(1), but not by a sphingomyelinase inhibitor, sphingomyelin analog-1 (SMA-1), suggesting that the tumor cells have a very effective means of synthesizing dihydroceramide and ceramide. "

Related Drugs and Biologics

1.	Sphingomyelins
2.	Sphingomyelin Phosphodiesterase (Sphingomyelinase)
3.	Enzymes
4.	Ceramides
5.	dihydroceramide
6.	fumonisin B1