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2,4,6- trimethyl- N- (meta- 3- trifluoromethylphenyl)benzenesulfonamide

stimulates phospholipase C; structure in first source

Also Known As:

m-3M3FBS

Networked: 11 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Jan, Chung-Ren: 4 articles (02/2014 - 01/2010)
2.	Liang, Wei-Zhe: 3 articles (02/2014 - 03/2012)
3.	Tsai, Jeng-Yu: 3 articles (02/2014 - 01/2010)
4.	Bae, Yoe-Sik: 3 articles (08/2012 - 05/2005)
5.	Chou, Chiang-Ting: 2 articles (02/2014 - 03/2012)
6.	Hsu, Shu-Shong: 2 articles (02/2014 - 02/2013)
7.	Liao, Wei-Chuan: 2 articles (02/2014 - 02/2013)
8.	Lin, Ko-Long: 2 articles (02/2014 - 02/2013)
9.	Liu, Shiuh-Inn: 2 articles (02/2014 - 02/2013)
10.	Lu, Ti: 2 articles (02/2014 - 02/2013)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 02/01/2017 - "The primary aim of the present study was to evaluate the physiological effects of the direct stimulation of PLC by m-3M3FBS on vascular smooth muscle reactivity in arteries pre-treated with lipopolysaccharides (LPS) as a model of septic shock. " 08/15/2012 - "In conclusion, we show that agonizing the central signal transducing enzyme PLC by m-3M3FBS can reverse the progression of toxic shock by triggering multiple protective downstream signaling pathways to maintain organ function, leukocyte survival, and to enhance microbial killing."
2.	Sepsis (Septicemia) 08/15/2012 - "Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis." 08/15/2012 - "In this study, we show that the direct PLC activator m-3M3FBS treatment significantly attenuates vital organ inflammation, widespread immune cell apoptosis, and mortality in a mouse sepsis model induced by lethal cecal ligation and puncture challenge. "
3.	Neuroblastoma 09/01/2004 - "In this study, we have investigated responses to the phospholipase C (PLC) activator m-3M3FBS in SH-SY5Y human neuroblastoma cells. "
4.	Inflammation (Inflammations) 08/15/2012 - "In this study, we show that the direct PLC activator m-3M3FBS treatment significantly attenuates vital organ inflammation, widespread immune cell apoptosis, and mortality in a mouse sepsis model induced by lethal cecal ligation and puncture challenge. "
5.	Vomiting 01/01/2021 - "We find that a 50 mg/kg (i.p.) dose of m-3M3FBS induces vomiting in ∼90% of tested least shrews, which was accompanied by significant increases in c-Fos expression and ERK1/2 phosphorylation in the shrew brainstem dorsal vagal complex, indicating activation of brainstem emetic nuclei in m-3M3FBS-evoked emesis. "

Related Drugs and Biologics

1.	Type C Phospholipases
2.	Lipopolysaccharides
3.	Caspases
4.	Cytokines
5.	Protein Kinase C
6.	Enzymes
7.	Emetics

Related Therapies and Procedures

1.	Punctures
2.	Ligation