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8- (4- chloro- phenylthio)- 2'- O- methyladenosine- 3'- 5'- cyclic monophosphate

epac-selective cAMP analog

Also Known As:

8-pCPT-2'-O-Me-cAMP; 8CPT-2Me-cAMP

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Price, Leo S: 3 articles (07/2014 - 05/2011)
2.	Qin, Yu: 3 articles (07/2014 - 05/2011)
3.	Stokman, Geurt: 3 articles (07/2014 - 05/2011)
4.	van de Water, Bob: 3 articles (07/2014 - 05/2011)
5.	Ramaiahgari, Sreenivasa: 2 articles (07/2014 - 02/2012)
6.	Schwede, Frank: 2 articles (07/2014 - 05/2011)
7.	Han, Yu-Zhang: 1 article (03/2022)
8.	Li, Xiao-Hui: 1 article (03/2022)
9.	Liu, Fu-You: 1 article (03/2022)
10.	Liu, Jia-Lu: 1 article (03/2022)

Related Diseases

1.	Renal Insufficiency (Renal Failure) 05/01/2011 - "Intrarenal administration in vivo of 8-pCPT-2'-O-Me-cAMP also reduced renal failure in a mouse model for ischemia-reperfusion injury. " 07/01/2014 - "Pharmacologic activation of Epac-Rap signaling by the Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP during ischemia-reperfusion (IR) injury reduces renal failure and application of 8-pCPT-2'-O-Me-cAMP promotes renal cell survival during exposure to the nephrotoxicant cisplatin. "
2.	Neoplasms (Cancer) 02/04/2021 - "Epac activator 8-pCPT-2'-O-Me-cAMP treatment could partially rescue proliferation of tumor cells. " 02/01/2012 - "In contrast, 8-pCPT-2'-O-Me-cAMP did not protect against cisplatin-induced cell death of cancer cells that lacked Epac1 expression. "
3.	Inflammation (Inflammations) 03/01/2022 - "We found that administering the Epac agonist 8-pCPT-2'-O-Me-cAMP (8-O-cAMP) to db/db mice inhibited tubulointerstitial inflammation characterized by macrophage infiltration and increased inflammatory cytokine release and consequently alleviated tubulointerstitial fibrosis in the kidney. " 12/18/2019 - "Then, airway inflammation and airway hyperresponsiveness in acute asthma mice model and airway remodeling in chronic asthma mice model were observed respectively after treatment with Epac-selective cAMP analogue 8-pCPT-2'-O-Me-cAMP (8pCPT) and Epac inhibitor ESI-09. "
4.	Airway Remodeling 12/18/2019 - "Then, airway inflammation and airway hyperresponsiveness in acute asthma mice model and airway remodeling in chronic asthma mice model were observed respectively after treatment with Epac-selective cAMP analogue 8-pCPT-2'-O-Me-cAMP (8pCPT) and Epac inhibitor ESI-09. "
5.	Reperfusion Injury 05/01/2011 - "Intrarenal administration in vivo of 8-pCPT-2'-O-Me-cAMP also reduced renal failure in a mouse model for ischemia-reperfusion injury. "

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Related Therapies and Procedures

1.	Aftercare (After-Treatment)