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Gb3 antigen

a synthetic antigen; structure in first source

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Biological Factors: 2472
- Biomarkers: 240291
  - Tumor Biomarkers: 15272
    - Carbohydrate Tumor-Associated Antigens: 355
      - Gb3 antigen: 7
- Antigens: 143924
  - Epitopes: 19548
    - Carbohydrate Tumor-Associated Antigens: 355
      - Gb3 antigen: 7
  - Neoplasm Antigens: 6217
    - Carbohydrate Tumor-Associated Antigens: 355
      - Gb3 antigen: 7

Related Diseases

1.	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 09/01/1991 - "Immunofluorescence mapping was performed using polyclonal antibodies from the serum of patients with bullous pemphigold and epidermolysis bullosa acquisita and monoclonal antibodies against GB3 antigen and collagen type VII. All but the bullous pemphigold serum gave positive results; only faint and focal staining of the dermoepidermal junction was observed with bullous pemphigold serum. "
2.	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 12/01/1990 - "In the Herlitz variant of junctional epidermolysis bullosa, GB3 antigen expression is consistently abnormal, but in the non-Herlitz and indeterminate forms of junctional epidermolysis bullosa, 40% of cases express GB3 antigen normally. " 12/01/1990 - "GB3 monoclonal antibody detects a normal basement membrane component (GB3 antigen) that is variably expressed in junctional epidermolysis bullosa. " 10/01/1992 - "Comparative immunoprecipitation studies of patient sera, P1E1, and GB3 monoclonal antibody show that epiligrin is identical to the antigen (i.e., BM600 or GB3 antigen) previously reported to be absent from the skin of patients with lethal junctional epidermolysis bullosa, an inherited subepidermal blistering disease. "
3.	Bullous Pemphigoid (Pemphigoid) 06/01/1993 - "Basement membrane-related antigens, including bullous pemphigoid antigen and GB3 antigen, were decreased in the epidermis. " 09/01/1992 - "Sections 4 microns thick taken from this cryofixed, freeze-dried, and paraffin-embedded skin were stained with hematoxylin-eosin or used for immunolabeling with antibodies against basement membrane antigen, including type IV and type VII collagen, bullous pemphigoid antigen, epidermolysis bullosa acquisita antigen, and GB3 antigen. "
4.	Colorectal Neoplasms (Colorectal Cancer) 10/01/2022 - "The Sortase A-catalyzed enzymatic tethering of rhamnose moieties to the C terminus of Stx1B and Stx2B had very moderate effect on their pentamer architectures and thus the resultant conjugates maintained the potent ability to bind to Gb3 antigen both immobilized on an assay plate and expressed on colorectal cancer cells. "
5.	Epidermolysis Bullosa 12/01/1990 - "In the majority of cases of the simplex and dystrophic forms of epidermolysis bullosa, GB3 antigen is normally expressed. "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	Collagen Type VII
3.	Antibodies
4.	Antigens
5.	Kalinin
6.	Rhamnose
7.	Paraffin
8.	Hematoxylin (Haematoxylon)
9.	Eosine Yellowish-(YS) (Eosin)
10.	sortase A