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CGP 76030

inhibits both Src and Abl protein kinases; structure in first source

Also Known As:

CGP-76030; CGP76030

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - CGP 76030: 3
  - Pyrimidines: 510
    - CGP 76030: 3

Experts

1.	Rucci, Nadia: 1 article (04/2008)
2.	Susa, Maria: 1 article (04/2008)
3.	Teti, Anna: 1 article (04/2008)
4.	Buchdunger, Elisabeth: 1 article (05/2004)
5.	Fabbro, Doriano: 1 article (05/2004)
6.	Hallek, Michael: 1 article (05/2004)
7.	Hu, Yiguo: 1 article (05/2004)
8.	Li, Shaoguang: 1 article (05/2004)
9.	Liu, Yuhua: 1 article (05/2004)
10.	Pelletier, Shawn: 1 article (05/2004)

Related Diseases

1.	Bone Resorption 04/01/2008 - "The pyrrolo-pyrimidines CGP77675 and CGP76030 proved to be effective in preventing bone loss in animal models, while the effect of AZD0530, a dually active inhibitor of c-Src and Bcr-ABL, on bone resorption, has been tested in a Phase I clinical trials with promising results. "
2.	Neoplasm Metastasis (Metastasis) 04/01/2008 - "In accord with this idea, CGP76030 is able to reduce the incidence of osteolytic lesions and of visceral metastases, and to suppress morbidity and lethality in a bone metastasis mouse model without obvious adverse effects. "
3.	Leukemia 05/01/2004 - "The biochemical target of CGP76030 in leukemia cells was Src kinases, not Bcr-Abl. "
4.	Carcinoma (Carcinomatosis) 09/01/2003 - "Two bona fide c-Src inhibitors, denominated CGP77675 and CGP76030, reduced in a time- and concentration-dependent manner (i) the proliferation of the PC3 prostate carcinoma cell line, as assessed by the [3H]-thymidine incorporation test, (ii) the capacity of PC3 cells to adhere and spread on Matrigel substrate, as determined by crystal violet staining, (iii) the ability of PC3 cells to migrate through a gelatine boundary and invade a Matrigel substrate. "

Related Drugs and Biologics

1.	CGP 77675
2.	Pyrimidines
3.	saracatinib
4.	src-Family Kinases
5.	Thymidine
6.	Gentian Violet (Violet, Crystal)
7.	matrigel