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DR-4004

a tetrahydrobenzindole

Also Known As:

2a-(4-(4-phenyl-1,2,3,6-tetrahydropyridyl)butyl)-2a,3,4,5-tetrahydrobenzo(cd)indol-2(1H)-one; DR4004

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - DR-4004: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - DR-4004: 2

Experts

1.	Balcer, Olivia M: 1 article (01/2019)
2.	Falcone, Julie: 1 article (01/2019)
3.	Gleason, Scott D: 1 article (01/2019)
4.	Li, Xia: 1 article (01/2019)
5.	Maxwell, Julia: 1 article (01/2019)
6.	Svensson, Kjell: 1 article (01/2019)
7.	Witkin, Jeffrey M: 1 article (01/2019)
8.	Fone, Kevin C F: 1 article (08/2002)
9.	Kogan, Helen A: 1 article (08/2002)
10.	Marsden, Charles A: 1 article (08/2002)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2019 - "Effects of DR-4004 and SB-269970 in animal models are generally consistent with the experimental literature that the evidence is mixed or not robust regarding the potential efficacy of 5-HT7 receptor antagonism in the treatment of anxiety, depression, or schizophrenia." 01/01/2019 - "Two selective 5-HT7 receptor antagonists, DR-4004 and SB-269970, were evaluated in mouse models used to detect drugs used to treat anxiety, depression, or schizophrenia. "
2.	Hypothermia 01/01/2019 - "A 5-HT-induced hypothermia assay was used to define the doses of DR-4004 and SB-269970 predicted to impact 5-HT7 receptors in the brain in vivo. " 08/02/2002 - "In conscious rats DR4004 (1, 5 or 10 mg/kg i.p.) produced a dose-dependent hyperglycaemia and hypothermia, but the former was reduced by the dopamine D2 receptor antagonist raclopride. " 01/01/2019 - "Doses of DR-4004 and SB-269970 that blocked 5-HT-induced hypothermia, did not display significant anxiolytic-like (elevated plus maze; vogel conflict) or antidepressant-like efficacy (tail-suspension test) in mouse models. "

Related Drugs and Biologics

1.	SB 269970
2.	serotonin 7 receptor
3.	Dopamine D2 Receptor Antagonists
4.	Raclopride
5.	Anti-Anxiety Agents (Anxiolytics)
6.	Antidepressive Agents (Antidepressants)