tenuiorin

orcinol derivative from the lichen Peltigera leucophlebia (Peltigeraceae); structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 10/01/2002 - "As correlation between 5-lipoxygenase inhibition and antiproliferative effects has earlier been witnessed for related lichen metabolites, tenuiorin and methyl orsellinate were further tested for antiproliferative activity on cultured human breast (T-47D)-, pancreatic (PANC-1)- and colon (WIDR) cancer cell lines. "
2.	Colonic Neoplasms (Colon Cancer) 10/01/2002 - "The monomeric methyl orsellinate exhibited no detectable antiproliferative activity whereas the trimeric tenuiorin caused moderate/weak reduction in [3H]-thymidine uptake of the pancreatic- and colon cancer cells, with ED50 values of 87.9 and 98.3 microM respectively."

1.	Thymidine
2.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
3.	methyl orsellinate