diphoterine

an amphoteric, polyvalent, hypertonic and chelating molecule with at least one site able to capture each kind of the 6 possible reactions (acid, base, oxydation, reduction, solvatation, chelation); used as an eye/skin chemical splash water-based decontamination solution; called Previn in Germany and Diphoterine elsewhere;

Also Known As:

Networked: 22 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hall, Alan H: 4 articles (01/2009 - 08/2002)
2.	Mathieu, Laurence: 4 articles (01/2009 - 08/2002)
3.	Frentz, M: 3 articles (07/2006 - 09/2003)
4.	Alexander, K Skaria: 2 articles (01/2018 - 01/2018)
5.	Cleland, Heather: 2 articles (01/2018 - 01/2018)
6.	Wasiak, Jason: 2 articles (01/2018 - 01/2018)
7.	Schrage, N F: 2 articles (07/2006 - 04/2004)
8.	Blomet, Joël: 2 articles (01/2006 - 07/2005)
9.	Kompa, Sirpa: 2 articles (12/2002 - 04/2002)
10.	Allison, Keith P: 1 article (01/2018)

Related Diseases

1.	Burns 06/01/2017 - "The safety and efficacy of Diphoterine for ocular and cutaneous burns in humans." 12/01/2002 - "After 30s of burn with 1N NaOH and rinsing with 500 ml of the specified solutions the anterior chamber pH was 10+/-0 in the saline group and 9.35+/-0.3 in the Diphoterine group showing efficacy of the buffering capacity of Diphoterine. " 08/01/2012 - "Irrigation with diphoterine was found in one study that resulted in better ocular outcomes following grade 1 and 2 ocular burns. " 01/01/2006 - "Following Diphoterine decontamination, no burns developed and there were no requirements for burn treatment or sequelae. " 03/01/2005 - "The time elapsed to reepithelialization is shorter with Diphoterine* for grade 1 and 2 burns. "
2.	Chemical Burns (Chemical Burn) 06/01/2017 - "Review the safety and efficacy of Diphoterine for treating chemical burns of the skin and eyes in humans. " 01/01/2018 - "Chemical burns: Diphoterine untangled." 06/01/2017 - "Published data must have included Diphoterine in the treatment of chemical burns on the skin or eyes as well as meet other specified criteria. " 08/01/2010 - "There were no signs of chemical burn in 52.9% of the group who applied Diphoterine first compared with 21.4% of the group who applied water first. " 01/01/2009 - "Diphoterine has more recently been used in hospitals for delayed management of chemical burns to the skin and eyes. "
3.	Wounds and Injuries (Trauma) 09/01/2015 - "The control group included five patients with similar injury patterns who were treated with Diphoterine(®) and occlusive wound dressings. " 03/31/2015 - "There was a significant change in the wound pH pre- and post-application of Diphoterine(®), compared to patients who were treated with water irrigation only, with a pH change of 1.076 vs 0.4 (p <0.05). " 01/01/2009 - "Safety of dermal diphoterine application: an active decontamination solution for chemical splash injuries." 04/01/2002 - "Therefore, we recommend solutions with low osmolarity (tap water) or high buffer capacity (Previn) for the initial post-trauma irrigation." 03/31/2015 - "patients admitted with chemical burns within 24 hours of the incident with an abnormal wound pH or in pain, were treated with Diphoterine(®) spray. "
4.	Pain (Aches) 01/01/2018 - "Clinical studies showed reduced tissue necrosis/severity of symptoms, faster pH resolution and a reduction in pain when using Diphoterine. " 08/01/2002 - "Diphoterine can prevent eye/skin burns following chemical splashes and results in nearly immediate pain relief." 03/31/2015 - "patients admitted with chemical burns within 24 hours of the incident with an abnormal wound pH or in pain, were treated with Diphoterine(®) spray. "
5.	Necrosis 01/01/2018 - "Pre-clinical studies showed a faster resolution of pH and reduced tissue necrosis with Diphoterine. " 01/01/2018 - "Clinical studies showed reduced tissue necrosis/severity of symptoms, faster pH resolution and a reduction in pain when using Diphoterine. "

Related Drugs and Biologics

1.	Sodium Hydroxide (Caustic Soda)
2.	Saline Solution
3.	Alkalies
4.	Buffers
5.	Acids
6.	Borates
7.	Substance P
8.	Calcium Gluconate (CBG)
9.	beta-Endorphin (Endorphin, beta)
10.	poly(lactide- co- trimethylenecarbonate- co- epsilon- caprolactone)

Related Therapies and Procedures

1.	Pain Management
2.	Artificial Skin
3.	First Aid (Aids, First)
4.	Aftercare (After-Treatment)