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9- (3- fluoro- 1- hydroxy- 2- propoxy)methylguanine

Also Known As:

((18)F)FHPG; 9-((3-((18)F)fluoro-1-hydroxy-2-propoxy)methyl)guanine; 9-(3-(18F)fluoro-1-hydroxy-2-propoxy)methylguanine; 9-FHPMG cpd

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        Acyclovir: 4814
        Ganciclovir: 3793
        9-(3-fluoro-1-hydroxy-2-propoxy)methylguanine: 3

Experts

1.	Mulder, N H: 3 articles (06/2005 - 02/2000)
2.	Vaalburg, W: 3 articles (06/2005 - 02/2000)
3.	van Waarde, A: 3 articles (06/2005 - 02/2000)
4.	Buursma, A R: 2 articles (06/2005 - 12/2004)
5.	Hospers, G A P: 2 articles (06/2005 - 12/2004)
6.	de Vries, E F J: 2 articles (06/2005 - 12/2004)
7.	Garssen, J: 1 article (06/2005)
8.	Kegler, D: 1 article (06/2005)
9.	Klein, H C: 1 article (06/2005)
10.	Schirm, J: 1 article (06/2005)

Related Diseases

1.	Infections 06/01/2005 - "Phosphor storage images showed an enhanced accumulation of [(18)F]FHPG in regions known to be affected after intranasal infection with HSV. " 02/01/2000 - "Therefore, [(18)F]FHPG appears to be the more selective tracer not only to predict HSV-tk gene therapy outcome, but also to localize active HCMV infections with PET." 02/01/2000 - "[(11)C]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ([(11)C]FMAU) and [(18)F]-9-[(3-fluoro-1-hydroxy-2-propoxy)methyl]guanine ([(18)F]FHPG), radiolabeled representatives of two classes of antiviral agents, were evaluated as tracers for measuring herpes simplex virus thymidine kinase (HSV-tk) enzyme activity after gene transfer and as tracers for localization of active human cytomegalovirus (HCMV) infections. "
2.	Glioma (Gliomas) 12/13/2004 - "Since membrane transport is an important aspect of the pharmacokinetics of the prodrug, we investigated the cellular uptake mechanism of [(18)F]FHPG in an HSVtk expressing C6 rat glioma cell line and in tumour-bearing rats. "
3.	Encephalitis (Encephalitis, Rasmussen) 06/01/2005 - "Our results show that [(18)F]FHPG PET is a promising tool for the detection of HSV encephalitis."
4.	Cytomegalovirus Infections (Inclusion Disease) 02/01/2000 - "[(11)C]FMAU and [(18)F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections."

Related Drugs and Biologics

1.	Thymidine Kinase
2.	Prodrugs
3.	Guanine
4.	Enzymes
5.	Arabinofuranosyluracil (Ara U)
6.	Antiviral Agents (Antivirals)
7.	clevudine