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XIB 4035

a GFRalpha-1 agonist; structure in first source

Also Known As:

N(4)-(7-chloro-2-((E)-2-(2-chlorophenyl)vinyl)quinolin-4-yl)-N(1),N(1)-diethylpentane-1,4-diamine; XIB4035

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - XIB 4035: 2

Experts

1.	Chiang, Hao: 1 article (01/2018)
2.	Hsieh, Sung-Tsang: 1 article (01/2018)
3.	Hsieh, Yu-Lin: 1 article (01/2018)
4.	Kan, Hung-Wei: 1 article (01/2018)
5.	Lee, Yi-Chen: 1 article (01/2018)
6.	Chaki, Shigeyuki: 1 article (01/2003)
7.	Nishiguchi, Mariko: 1 article (01/2003)
8.	Okuyama, Shigeru: 1 article (01/2003)
9.	Sakai, Masahiko: 1 article (01/2003)
10.	Sekine, Takumi: 1 article (01/2003)

Related Diseases

1.	Neuroblastoma 01/01/2003 - "We investigated the agonistic activities of N(4)-(7-chloro-2-[(E)-2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl)-N(1),N(1)-diethyl-pentane-1,4-diamine (XIB4035), at the glial cell line-derived neurotrophic factor (GDNF) family receptoralpha-1(GFRalpha-1) in Neuro-2A cells, a mouse neuroblastoma cell line which is a suitable model for investigating functions mediated through GFRalpha-1. "
2.	Hyperalgesia 01/01/2018 - "The activation of Ret signaling by XIB4035 induced mechanical allodynia and thermal hypoalgesia in RTX neuropathy mice in which the neuropathic behaviors were previously normalized by 4MC. "

Related Drugs and Biologics

1.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)
2.	Diamines
3.	pentane