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purmorphamine

structure in first source

Also Known As:

9H-purin-6-amine, 9-cyclohexyl-N-(4-(4-morpholinyl)phenyl)-2-(1-naphthalenyloxy)-

Networked: 17 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - purmorphamine: 17
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - purmorphamine: 17

Experts

1.	Bai, Xuemei: 2 articles (01/2020 - 01/2016)
2.	Wang, Zhen: 2 articles (01/2020 - 01/2016)
3.	Xin, Danqing: 2 articles (01/2020 - 01/2016)
4.	Al-Mazroua, Haneen A: 1 article (03/2022)
5.	Alharbi, Metab: 1 article (03/2022)
6.	Alshammari, Abdulrahman: 1 article (03/2022)
7.	Gupta, Ria: 1 article (03/2022)
8.	Mehan, Sidharth: 1 article (03/2022)
9.	Narula, Acharan S: 1 article (03/2022)
10.	Prajapati, Aradhana: 1 article (03/2022)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 09/01/2004 - "These results demonstrate that purmorphamine is a small molecule agonist of Hedgehog signaling, and it may ultimately be useful in the treatment of bone-related disease and neurodegenerative disease."
2.	Autistic Disorder (Autism) 11/01/2021 - "Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism."
3.	Brain Injuries (Brain Injury) 01/01/2016 - "The present study was undertaken to evaluate the influence of an agonist of the Shh co-receptor Smoothened (Smo), purmorphamine (PUR), on early brain injury (EBI) as well as the underlying mechanisms after SAH. "
4.	Ischemic Stroke 01/01/2020 - "Purmorphamine (PUR), an agonist of the Smoothened (Smo) receptor, has been shown to function as a neuroprotectant in acute experimental ischemic stroke. " 10/23/2014 - "Here we report the neuroprotective properties of a small-molecule agonist of the Shh co-receptor Smoothened, purmorphamine (PUR), in the middle cerebral artery occlusion model of ischemic stroke. "
5.	Drug-Related Side Effects and Adverse Reactions 06/01/2011 - "Purmorphamine and β-TCP incorporation in PPLM adhesives might, therefore, provide prolonged enhancement of in vivo bone repair without systemic drug side-effects."

Related Drugs and Biologics

1.	propionic acid (potassium propionate)
2.	Smoothened Receptor
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Small Interfering RNA (siRNA)
5.	Neuroprotective Agents
6.	Metformin (Glucophage)
7.	cyclopamine