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ISIS 25302

binds murine TNF-alpha mRNA to encourage degradation of the mRNA as well as preventing translation

Also Known As:

ISIS-25302; ISIS25302

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Oligonucleotides: 5145
      - Phosphorothioate Oligonucleotides: 65
        ISIS 25302: 1

Experts

1.	Baker, Brenda: 1 article (01/2003)
2.	Butler, Madeline: 1 article (01/2003)
3.	Flanigan, Anne: 1 article (01/2003)
4.	Goodfellow, Deborah: 1 article (01/2003)
5.	Madsen, Karen: 1 article (01/2003)
6.	Murray, Susan: 1 article (01/2003)
7.	Murthy, Sreekant: 1 article (01/2003)
8.	Myers, Kathleen J: 1 article (01/2003)
9.	Siwkowski, Andrew: 1 article (01/2003)
10.	Witchell, Donna R: 1 article (01/2003)

Related Diseases

1.	Colitis 01/01/2003 - "ISIS 25302 significantly reduced disease activity index scores in mice with both an acute and a chronic form of dextran sodium sulfate (DSS)-induced colitis. "
2.	Inflammation (Inflammations) 01/01/2003 - "We have developed a second-generation antisense oligonucleotide (ISIS 25302) specific for murine TNF-alpha and have evaluated this oligonucleotide in two models of gut inflammation of distinct etiology. "

Related Drugs and Biologics

1.	Dextrans (Dextran)
2.	sodium sulfate (sodium bisulfate)
3.	Antisense Oligonucleotides
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Oligonucleotides