HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

ER37328

structure in first source

Also Known As:

12,13-dihydro-5-(2-(dimethylamino)ethyl)-4H-benzo(c)pyrimido(5,6,1- jk)carbazole-4,6,10(5H,11H)-trione hydrochloride; ER-37328

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - ER37328: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        ER37328: 3
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - ER37328: 3

Experts

1.	Nakamura, Katsuji: 3 articles (01/2003 - 01/2002)
2.	Yoshimatsu, Kentaro: 3 articles (01/2003 - 01/2002)
3.	Kamata, Junichi: 2 articles (01/2003 - 01/2002)
4.	Kitoh, Kyosuke: 2 articles (01/2003 - 01/2002)
5.	Kotake, Yoshihiko: 2 articles (01/2003 - 01/2002)
6.	Koyanagi, Nozomu: 2 articles (01/2003 - 01/2002)
7.	Nagasu, Takeshi: 2 articles (01/2003 - 01/2002)
8.	Niijima, Jun: 2 articles (01/2003 - 01/2002)
9.	Okada, Toshimi: 2 articles (01/2003 - 01/2002)
10.	Sugumi, Hiroyuki: 2 articles (01/2003 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2003 - "Here, we describe studies on the cell-killing activity against a panel of human cancer cell lines and the antitumor activity of ER-37328 against human tumor xenografts. " 01/01/2003 - "Pharmacokinetic study revealed that ER-37328 was highly distributed to the tumor and organs. " 01/01/2003 - "This high distribution to the tumor and liver may explain the potent antitumor activity of ER-37328 against Colon 38 tumor in the liver. " 01/01/2003 - "The ratios of the area under the concentration-time curves of ER-37328 in the tumor, lung, liver, and kidney versus plasma were 81, 77, 47, and 40, respectively. " 01/01/2003 - "ER-37328 showed strong tumor-regression activity against Colon 38 growing in the liver. "
2.	Neoplasm Metastasis (Metastasis) 01/01/2003 - "On the later schedule, ER-37328 completely blocked liver metastasis, whereas the mean number of metastases in the control group was 23.9. " 01/01/2003 - "Here, we describe studies on the effects of ER-37328 on the primary tumor, liver metastasis, and survival in a murine Colon 38 orthotopic transplantation model. " 01/01/2003 - "Effects of ER-37328 on primary tumor, liver metastasis, and life span in a murine colon 38 orthotopic transplantation model."
3.	Leukemia P388 01/01/2002 - "ER-37328 inhibited topoisomerase II activity at 10 times lower concentration than etoposide in relaxation assay and induced double-strand DNA cleavage within 1 h in murine leukemia P388 cells, in a bell-shaped manner with respect to drug concentration. "
4.	Colonic Neoplasms (Colon Cancer) 01/01/2003 - "In conclusion, the topoisomerase II poison ER-37328 is a promising candidate for clinical application against colon cancer."
5.	Carcinoma (Carcinomatosis) 01/01/2002 - "In vivo, ER-37328 produced potent tumor regression of Colon 38 carcinoma inoculated s.c., and its activity was superior to that of etoposide or doxorubicin. "

Related Drugs and Biologics

1.	Type II DNA Topoisomerases (Topoisomerase II)
2.	Poisons
3.	Etoposide (VP 16)
4.	Doxorubicin (Adriamycin)
5.	Dihydrotachysterol (AT 10)
6.	Cisplatin (Platino)
7.	Irinotecan (Camptosar)
8.	trioctyl phosphine oxide (TOPO)
9.	carbazole
10.	montirelin (NS-3)

Related Therapies and Procedures

1.	Transplantation