human MGr1-antigen

01/01/2006 - "Initial studies using the introduction of sense or antisense vectors for MGr1-Ag resulted in the genetical up- or downregulation of MGr1-Ag in gastric cancer cells, respectively. "
01/01/2002 - "The aim of this study was to characterize the role of MGr1-Ag in the multidrug resistance of gastric cancer cells. "
01/01/2006 - "In conclusion, MGr1-Ag may promote MDR of gastric cancer cells via a decrease in intracellular drug accumulation and inhibition of drug-induced apoptosis."
01/01/2006 - "Overexpression of exogenous MGr1-Ag may promote the MDR phenotype of gastric cancer cells, decrease intracellular ADM accumulation and protect gastric cancer cells from ADM-induced apoptosis, whereas downregulation of MGr1-Ag had reverse effects. "
01/01/2006 - "The expression level of MGr1-Ag in MDR gastric cancer cells is much higher than that in their parental cells. "

06/01/2013 - "MGr1-Ag promotes invasion and bone metastasis of small-cell lung cancer in vitro and in vivo."

09/22/2017 - "As the salient ligand molecule of PrP for participating in internalization and propagation of the scrapie form of prion protein (PrPSc), 37 kDa laminin receptor precursor protein (37LRP) shared the same gene coding sequence of MGr1-Ag, another protein previously found to be involved in multi-drug-resistance of gastric cancer in our lab. "

01/01/2006 - "Previously, a novel protein, MGr1-Ag, was associated with tumor multidrug resistance (MDR), and the role and the underlying mechanisms of MGr1-Ag in MDR of gastric cancer cells were characterized. "

06/01/2013 - "Taken together, we conclude that MGr1-Ag promotes SCLC cell invasion and bone metastasis in vitro and in vivo, and that this is partially mediated via the EMT pathway."
06/01/2013 - "Using a sense vector to upregulate MGr1-Ag expression in SBC-3 cells, we found that forced overexpression of MGr1-Ag enhanced cell invasion and migration in vitro and promoted bone metastases in vivo. "
06/01/2013 - "Therefore, we hypothesized that MGr1-Ag is involved in bone metastasis of SCLC. "
06/01/2013 - "MGr1-Ag promotes invasion and bone metastasis of small-cell lung cancer in vitro and in vivo."
06/01/2013 - "Furthermore, specific siRNA-induced knockdown of MGr1-Ag expression in SBC-5 cells suppressed the potential of cell invasion and migration in vitro and dramatically decreased the number and sites of bone metastasis in vivo. "