(north)-methanocarbathymidine

also called NMCT

Also Known As:

(N)-MCT; 1-((1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-bicyclo(3.1.0)hexanyl)-5-methylpyrimidine-2,4-dione; 1-((1S,2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)bicyclo(3.1.0)hexan-2-yl)thymine; N-methanocarbathymidine

Networked: 15 relevant articles (5 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Thymidine: 4460
        (north)-methanocarbathymidine: 15
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Thymidine: 4460
      - (north)-methanocarbathymidine: 15
  - Deoxyribonucleosides: 34
    - Thymidine: 4460
      - (north)-methanocarbathymidine: 15

Experts

1.	Agbaria, Riad: 6 articles (01/2007 - 06/2002)
2.	Marquez, Victor E: 5 articles (09/2006 - 06/2002)
3.	Rahman, Aquilur: 4 articles (02/2015 - 11/2007)
4.	Smee, Donald F: 4 articles (01/2008 - 01/2007)
5.	Ford, Harry: 4 articles (05/2005 - 06/2002)
6.	Johns, David G: 4 articles (05/2005 - 06/2002)
7.	Bernstein, David I: 2 articles (02/2015 - 11/2011)
8.	Bravo, Fernando J: 2 articles (02/2015 - 11/2011)
9.	Cardin, Rhonda D: 2 articles (02/2015 - 11/2011)
10.	Glazer, Robert I: 2 articles (02/2015 - 11/2007)

Related Diseases

1.	Infections 11/17/2011 - "Efficacy of orally administered low dose N-methanocarbathymidine against lethal herpes simplex virus type-2 infections of mice." 01/01/2007 - "(N)-MCT treatment at 100 and 30 mg/kg/day resulted in 90 and 20% survival from cowpox virus infection, respectively, compared to 0% survival in the placebo group. " 02/01/2015 - "Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs." 05/01/2005 - "Continuous treatment of Vero cells with (N)-MCT immediately or 10 h post-infection (p.i.) fully prevented the development of viral infection. " 07/01/2002 - "Treatment of HSV-1 infected Vero cells immediately after viral infection with (N)-MCT profoundly inhibited the development of HSV-1 infection. "
2.	Poxviridae Infections 11/01/2007 - "(N)-MCT could be further pursued for its potential to treat orthopoxvirus infections in humans." 04/01/2006 - "Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections." 01/01/2007 - "Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice." 01/01/2007 - "A novel carbocyclic thymidine analog, N-methanocarbathymidine [(N)-MCT], was evaluated for inhibition of orthopoxvirus infections. " 01/01/2008 - "New compounds showing promise are orally active inhibitors of orthopoxvirus infections that include ether lipid prodrugs of cidofovir and (S)-HPMPA, ST-246, N-methanocarbathymidine (N-MCT) and SRI 21950 (a 4'-thio derivative of iododeoxyuridine). "
3.	Herpesviridae Infections (Herpesvirus Infection) 04/01/2006 - "These results indicate that (N)-MCT is active in vitro and in vivo, and its mechanism of action suggests that the molecule may be an effective therapeutic for orthopoxvirus and herpesvirus infections, thus warranting further development."
4.	Herpes Genitalis (Genital Herpes) 02/01/2015 - "Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs."
5.	Acute Disease 02/01/2015 - "Treatment of the acute disease with N-methanocarbathymidine significantly reduced the severity of acute disease and decreased acute vaginal virus shedding more effectively than acyclovir. "

Related Drugs and Biologics

1.	(north)-methanocarbathymidine
2.	Acyclovir (Aciclovir)
3.	Antiviral Agents (Antivirals)
4.	Thymidine Kinase
5.	Prodrugs
6.	Cidofovir (Vistide)
7.	Thymidine
8.	Nucleosides
9.	triphosphoric acid (triphosphate)
10.	Carbasugars

Related Therapies and Procedures

1.	Therapeutics