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liver X receptor

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orphan receptor of nuclear receptor superfamily involved in retinoid response pathway; RefSeq NM_031627 (rat), NM_005693 (human), NM_013839 (mouse)

Also Known As:

LXR alpha protein, mouse; LXR-A protein, human; LXR-alpha protein; LXRA protein, human; LXRA protein, rat; LXRalpha protein; LXRbeta protein; NER protein, human; NR1H2 protein; NR1H2 protein, human; NR1H3 protein, human; Nr1h2 protein, mouse; Nr1h2 protein, rat; Nr1h3 protein, mouse; Nr1h3 protein, rat; Nuclear orphan receptor LXR-alpha; OR-1 protein, rat; RIP15 protein, human; RIP15 protein, mouse; RLD-1 protein, human; RLD-1 protein, rat; RLD1 protein, mouse; RXR-interacting protein 15, mouse; UR protein, mouse; liver X receptor alpha; liver X receptor alpha, rat; liver X receptor beta; nuclear receptor subfamily 1, group H, member 2; nuclear receptor subfamily 1, group H, member 2 protein, human; nuclear receptor subfamily 1, group H, member 2 protein, mouse; nuclear receptor subfamily 1, group H, member 2 protein, rat; nuclear receptor subfamily 1, group H, member 3; nuclear receptor subfamily 1, group H, member 3 protein, human; nuclear receptor subfamily 1, group H, member 3 protein, mouse; oxysterols receptor LXR-alpha; oxysterols receptor LXR-alpha, rat; oxysterols receptor LXR-beta

Networked: 325 relevant articles (6 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	Steffensen, Knut R: 10 articles (07/2015 - 01/2007)
2.	Kaul, Deepak: 9 articles (08/2013 - 10/2003)
3.	Gustafsson, Jan-Åke: 8 articles (05/2014 - 08/2011)
4.	Gustafsson, Jan-Ake: 8 articles (08/2013 - 06/2005)
5.	Tontonoz, Peter: 8 articles (06/2012 - 06/2003)
6.	Liao, Shutsung: 8 articles (07/2011 - 11/2004)
7.	Hiipakka, Richard A: 7 articles (07/2011 - 11/2004)
8.	Kokontis, John M: 6 articles (07/2011 - 11/2004)
9.	Warner, Margaret: 5 articles (08/2012 - 02/2008)
10.	Collins, Jon L: 5 articles (08/2011 - 02/2003)

Related Diseases

1.	Atherosclerosis 12/01/2011 - "Although animal studies indicate that liver X receptor alpha (LXRα) might influence risk of atherosclerosis, data in humans remain scarce. " 05/01/2008 - "Although a range of studies indicated Liver X receptor (LXR) activation inhibited the development of atherosclerosis in animal models, the mechanism of this effect for LXR agonists has not been fully understood. " 04/01/2003 - "Although potentially undesirable effects of liver X receptor activation on triglyceride metabolism have been observed, recent in-vivo studies confirm that the overall trend is a reduction of atherogenesis. " 06/01/2015 - "Liver X receptor activation promotes polyunsaturated fatty acid synthesis in macrophages: relevance in the context of atherosclerosis." 02/01/2014 - "Liver X receptor (LXR) activators decrease atherosclerosis in mice. "
2.	Type 2 Diabetes Mellitus (MODY) 05/27/2008 - "Upregulation of liver X receptor dramatically reduced foam cell formation in macrophages from patients with type 2 diabetes mellitus. " 01/01/2010 - "Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)." 08/01/1997 - "Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients."
3.	Memory Disorders (Memory Loss) 05/19/2010 - "Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice."
4.	Diabetic Nephropathies (Diabetic Nephropathy) 11/01/2012 - "Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy."
5.	Neoplasms (Cancer) 07/13/2015 - "In this issue of Cancer Cell, Flaveny and colleagues target the liver-X-receptor with an inverse agonist and show that key glycolytic and lipogenic genes are suppressed, leading to apoptosis of tumor cells without an effect on non-malignant cells. " 07/13/2015 - "Are Synthetic Compounds that Silence the Liver-X-Receptor the Next Generation of Anti-cancer Drugs?" 04/15/2014 - "Liver X receptor: from metabolism to cancer." 08/26/2013 - "We report that tumor-derived oxysterols recruit protumor neutrophils in a liver X receptor (LXR)-independent, CXCR2-dependent manner, thus favoring tumor growth by promoting neoangiogenesis and immunosuppression. " 01/01/2010 - "Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses."

Related Drugs and Biologics

1.	Cholesterol
2.	Peroxisome Proliferator-Activated Receptors (PPAR)
3.	GW 3965
4.	Amyloid (Amyloid Fibrils)
5.	HDL Cholesterol
6.	ezetimibe (Zetia)
7.	Osteopontin
8.	Antioxidants
9.	PPAR gamma
10.	pregnane X receptor

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Therapeutics
3.	Resuscitation
4.	Ligation