pemtumomab

a murine immunoglobulin G(1) MAb that recognizes an epitope on the polymorphic epithelial mucin (PEM) antigen

Also Known As:

HMFG1 MAb; R 1549; R-1549; monoclonal antibody HMFG1; theragyn

Networked: 14 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        pemtumomab: 14
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        pemtumomab: 14
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        pemtumomab: 14

Experts

1.	Massuger, Leon F A G: 1 article (08/2007)
2.	Oei, Angèle L M: 1 article (08/2007)
3.	Oyen, Wim J G: 1 article (08/2007)
4.	Benigno, Benedict B: 1 article (06/2007)
5.	Epenetos, Agamemnon A: 1 article (06/2007)
6.	Lopes, Alberto: 1 article (06/2007)
7.	Massuger, Leon F: 1 article (06/2007)
8.	Oei, Angèle L: 1 article (06/2007)
9.	Seiden, Michael V: 1 article (06/2007)
10.	Soper, John T: 1 article (06/2007)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2007 - "We conducted a single-arm study to determine the biodistribution of intraperitoneally (i.p.) administered 90yttrium-labeled murine monoclonal antibody HMFG1 (90Y-muHMFG1) in patients with advanced stage ovarian cancer. " 06/15/2007 - "This study analyzes the site of disease recurrence in ovarian cancer patients to assess the influence of a single intraperitoneal (IP) administration of yttrium-90-labeled murine monoclonal antibody HMFG1 ((90)Y-muHMFG1) on the pattern of disease recurrence. " 11/01/1990 - "Radioimmunoscintigraphy with I-123 labeled monoclonal antibody HMFG1 has been used for imaging primary and metastatic ovarian neoplasms. " 05/01/1995 - "The development of stable chelating agents for metal isotopes (e.g., 90Y) such as CITC-DTPA, a benzyl-analog of DTPA, allowed us to evaluate the efficacy of 90Y-labeled HMFG1 MAb administered intraperitoneally in patients with ovarian cancer. "
2.	Carcinoma (Carcinomatosis) 07/01/1990 - "A phase 1-2 trial of 90Y-labelled monoclonal antibody, HMFG1 administered intraperitoneally to 30 patients with ovarian carcinoma is presented. " 09/01/2003 - "In the present study, the therapeutic efficacy of RIT with murine monoclonal antibody HMFG1 labeled with three different beta-radiation emitting radionuclides (90Yttrium, 186Rhenium, and 131Iodine) was assessed in athymic BALB/c mice with intraperitoneally growing NIH:OVCAR-3 ovarian carcinoma xenografts. "
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 11/01/1990 - "In these preliminary studies, the monoclonal antibody HMFG1 was conjugated with streptavidin and 1 mg was administered intravenously to each of 10 patients with documented squamous cell carcinoma of the lung. "
4.	Ovarian Epithelial Carcinoma 08/01/1993 - "Fifty-two patients with epithelial ovarian cancer were treated with yttrium-90-labelled monoclonal antibody HMFG1 administered intraperitoneally following conventional surgery and chemotherapy as part of an extended phase I-II trial. "
5.	Neoplasms (Cancer) 02/15/1994 - "Kosmas et al. (Cancer Res., 52: 904-911, 1992) found 2-imminothiolane linker-(S)-BAD monoclonal antibody HMFG1 highly immunogenic in patients. " 04/01/1988 - "Immunoscintigraphy using F(ab')2 fragments of tumor-associated monoclonal antibody HMFG1 was performed in 14 patients with primary and metastatic non-small cell carcinoma of lung cancer. " 12/01/1990 - "They received escalating doses of intraperitoneally (IP) administered yttrium-90 (Y-90)-labeled monoclonal antibody, HMFG1, against a tumor cell-surface antigen. " 10/01/2003 - "R-1549 (formerly known as pemtumomab), a murine monoclonal antibody (HMFG1) specific for the cancer antigen PEM and radiolabeled with yttrium-90, is under development by Antisoma and Roche as a potential treatment for ovarian and gastric cancer. "

Related Drugs and Biologics

1.	Radioisotopes (Radionuclides)
2.	Metals
3.	Isotopes
4.	Pentetic Acid (DTPA)
5.	Chelating Agents
6.	6- (4- isothiocyanatobenzyl)- diethylenetriamine pentaacetic acid
7.	Streptavidin
8.	pemtumomab
9.	Yttrium-90
10.	Phenobarbital (Luminal)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)