GW 4869

01/01/2021 - "The inhibition of exosome secretion by Rab27a knockout or GW4869 treatment ameliorates renal fibrosis following UIRI in vivo. "
09/02/2021 - "The effects of GW4869, an exosomes inhibitor, on lung fibrosis were assessed. "
01/01/2021 - "Conclusions: The blockade of exosome release with GW4869 suppressed AF by alleviating atrial fibrosis in a canine model, which was probably related to profibrotic miR-21-5p enriched in exosomes and its downstream TIMP3/TGF-β1 pathway."
01/01/2021 - "In addition, the inhibition of exosome secretion by Rab27a knockout or GW4869 treatment abolished fibroblast activation and ameliorated renal fibrosis. "
11/01/2019 - "Local injection in the late scar formation period with GW4869 reduced α-SMA+ fibroblasts and alleviated the fibrosis of tissue after wound healing in vivo.-Chen, J., Zhou, R., Liang, Y., Fu, X., Wang, D., Wang, C. "

01/01/2023 - "We found that the reduction in tumor sEVs secretion induced by GW4869 improved the tumor-suppressive immune microenvironment. "
05/01/2023 - "The effects of GW4869 and SCC7-EVs on xenograft tumor proliferation and invasion were investigated by tumor volume determination and histopathological examination. "
12/01/2022 - "GW4869 was injected intra-tumorally after tumor implantation. "
01/01/2022 - "Furthermore, GW4869 treatment (IP) in mice bearing PC3-R xenografts significantly reduced the tumor weight (65% reduction, P = 0.017) compared to the vehicle-treated control mice without causing any noticeable toxicity. "
01/01/2022 - "Importantly, treatment with GW4869 significantly inhibited the release of exosomes from PCa cells, and further impaired M2 differentiation of macrophages and their pro-tumor activity. "

12/01/2016 - "Using a transwell system and exosome release inhibitor GW4869, we demonstrated that mature DCs contributed to endothelial inflammation and exosomes were involved in the process. "
01/01/2022 - "Accordingly, we hypothesized that nSMase inhibition with GW4869, would attenuate Western diet (WD) - induced increases in aortic stiffness through alterations in pathways which lead to oxidative stress, inflammation and vascular remodeling. "
11/01/2015 - "Accordingly, GW4869 treatment diminished the sepsis-induced cardiac inflammation, attenuated myocardial depression and prolonged survival. "
11/01/2015 - "Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction."
01/01/2020 - "Interestingly, immunohistochemical study showed that amitriptyline, but not GW4869, strongly reduced hepatic inflammation. "

01/01/2021 - "Strikingly, inhibition of EV production using GW4869 resulted in protection against acute AβO-induced cognitive decline. "
12/01/2021 - "GW4869 mitigated sevoflurane-induced cognitive impairment in mice. "
07/15/2021 - "FPS-ZM1 (an inhibitor of RAGE), myriocin and GW4869 (an inhibitor of ceramide) were used to explore the role of S100B/RAGE/ceramide in acute brain injury and long-term cognitive impairment in sepsis. "

11/27/2023 - "Moreover, the inflammatory response and remote organ (kidney and lung) injury associated with SAP improved after GW4869 treatment. "
01/01/2021 - "We found that intratracheal GW4869 administration ameliorated lung injury following CLP-induced ALI. "
01/01/2021 - "The effect of exosomal inhibition by intratracheal GW4869 administration on lung injury was investigated. "