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BPDZ 154

activates ATP-sensitive potassium channels; structure in first source

Also Known As:

6,7-dichloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide; BPDZ-154; BPDZ154

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiadiazines: 3
      - BPDZ 154: 1
- Heterocyclic Oxides
  - Cyclic S-Oxides
    - BPDZ 154: 1

Experts

1.	Antoine, Marie-Hélène: 1 article (11/2002)
2.	Aynsley-Green, Al: 1 article (11/2002)
3.	Barnes, Philippa D: 1 article (11/2002)
4.	Clayton, Peter: 1 article (11/2002)
5.	Cosgrove, Karen E: 1 article (11/2002)
6.	De Lonlay, Pascal: 1 article (11/2002)
7.	Dunne, Mark J: 1 article (11/2002)
8.	Hussain, Khalid: 1 article (11/2002)
9.	Lebrun, Philippe: 1 article (11/2002)
10.	Lee, Anne T: 1 article (11/2002)

Related Diseases

1.	Hyperinsulinism (Hyperinsulinemia) 11/01/2002 - "These data suggest that BPDZ 154 or BPDZ 154-like compounds may have therapeutic potential in the treatment of certain forms of hyperinsulinism." 11/01/2002 - "BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism." 11/01/2002 - "By contrast, it was not possible to activate K(ATP) channels by either diazoxide or BPDZ 154 in beta-cells from patients with hyperinsulinism as a consequence of defects in K(ATP) channel function. " 11/01/2002 - "In beta-cells isolated from patients with either nontypical hyperinsulinism (preserved K(ATP) channel function) or from the control areas of the pancreas of patients with focal hyperinsulinism, BPDZ 154 activated K(ATP) channels and was found to be more effective and less readily reversible than diazoxide. "
2.	Insulinoma 11/01/2002 - "In beta-cells isolated from a patient with pancreatic insulinoma, K(ATP) channels were readily recorded and modulated by BPDZ 154. "

Related Drugs and Biologics

1.	Potassium Channels (Potassium Channel)
2.	Adenosine (Adenocard)
3.	Diazoxide (Hyperstat)
4.	Adenosine Triphosphate (ATP)