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JTE 607

a multiple cytolkine inhibitor

Also Known As:

(-)-ethyl N-(3,5-dichloro-2-hydroxy-4-(2-(4-methylpiperazin-1-yl))ethoxybenzoyl)-L-phenylamine dihydrochloride; JTE-607

Networked: 12 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Essential Amino Acids: 1152
    - Phenylalanine: 4090
      - JTE 607: 12
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 467
      - Phenylalanine: 4090
        JTE 607: 12
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - JTE 607: 12

Experts

1.	Yoshida, Takayuki: 2 articles (10/2019 - 03/2010)
2.	Fukui, Kenji: 2 articles (03/2010 - 10/2006)
3.	Maruhashi, Junji: 2 articles (03/2010 - 10/2006)
4.	Tajima, Nobuyuki: 2 articles (03/2010 - 10/2006)
5.	Tojo, Arinobu: 2 articles (03/2010 - 10/2006)
6.	Uesato, Naofumi: 2 articles (03/2010 - 10/2006)
7.	Akinjiyan, Favour A: 1 article (01/2020)
8.	Artus-Revel, Caroline G: 1 article (01/2020)
9.	Beckwith, Rohan E J: 1 article (01/2020)
10.	Boynton, Geoffrey: 1 article (01/2020)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/01/2006 - "JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model." 03/01/2010 - "JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells."
2.	Necrosis 07/01/2008 - "JTE-607 reduced the I/R-induced increases in the serum concentrations of blood urea nitrogen and creatinine, and improved the histopathologic changes, including acute tubular necrosis. "
3.	Leukemia 10/01/2006 - "In the present study, we investigated the potency of JTE-607 as an antileukemic agent by exploiting a SCID mouse acute leukemia model. " 10/01/2006 - "Delayed administration of JTE-607 also prolonged the survival of mice bearing established leukemia with an effect comparable to the maximum tolerable dose of cytarabine. " 10/08/2019 - "JTE-607 is a small molecule that was developed as an inflammatory cytokine inhibitor and also as an anti-leukemia reagent for monocytic leukemia. " 03/01/2010 - "In a leukemia model engrafted with U-937 cells, JTE-607 significantly prolonged survival in mice and reduced human cytokine mRNA levels in the bone marrow. "
4.	Endotoxemia 11/01/2011 - "In conclusion, this study describes a cytokine modulator JTE-607, which inhibits production of IL-10, IL-1ra and C-reactive protein in a human model of endotoxemia."
5.	Myocardial Ischemia (Ischemic Heart Diseases) 06/01/2004 - "In this study we proved the hypothesis that JTE-607 might attenuate myocardial ischemia-reperfusion injury in a rat model. "

Related Drugs and Biologics

1.	Cytokines
2.	Urea (Carbamide)
3.	Nitrogen
4.	Creatinine
5.	Interleukin 1 Receptor Antagonist Protein (Anakinra)
6.	Interleukin-10 (Interleukin 10)
7.	Dexamethasone (Maxidex)
8.	C-Reactive Protein
9.	Messenger RNA (mRNA)
10.	Interleukins

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Punctures
3.	Ligation