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A 182086

an endothelin receptor antagonist; structure in first source

Also Known As:

A-182086; A182086

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - A 182086: 4
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - A 182086: 4
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - A 182086: 4

Experts

1.	Pollock, David M: 1 article (07/2011)
2.	Pollock, Jennifer S: 1 article (07/2011)
3.	Saleh, Mohamed A: 1 article (07/2011)
4.	Albini, Adriana: 1 article (08/2003)
5.	Bagnato, Anna: 1 article (08/2003)
6.	Di Castro, Valeriana: 1 article (08/2003)
7.	Natali, Pier Giorgio: 1 article (08/2003)
8.	Nicotra, Maria Rita: 1 article (08/2003)
9.	Rosanò, Laura: 1 article (08/2003)
10.	Spinella, Francesca: 1 article (08/2003)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 08/01/1999 - "2. To further elucidate the specific role of the ETA as opposed to the ETB receptor and their effects in the splanchnic region a non-selective (ET(MIX)ra) A-182086 and selective ETA (ET(A)ra) PD155080 and ETB (ET(B)ra) A-192621 receptor antagonists were administered, separately or simultaneously (ET(A+B)ra) 2 h after onset of endotoxin shock. "
2.	Proteinuria 07/01/2011 - "Daily administration of both ABT-627 and A-182086 for 1 week significantly attenuated proteinuria, the increase in P(alb), nephrinuria, and total MMP and TGF-β1 activity. "
3.	Neoplasms (Cancer) 08/01/2003 - "The small molecule, A-182086, an orally bioavailable ET(A/B)R antagonist, completely inhibited cell proliferation and tumor growth in KS IMM xenografts. "
4.	Hypertension (High Blood Pressure) 11/01/2001 - "The chronic hypertensive effect of A-192621 was not significantly affected by salt intake or ANG II. The administration of A-182086 lowered arterial pressure chronically only in rats on normal salt intake receiving ANG II. Thus the salt sensitivity of ANG II-induced hypertension is not caused by changes in ETB receptor function."

Related Drugs and Biologics

1.	A 192621
2.	Matrix Metalloproteinases (MMPs)
3.	Salts
4.	Atrasentan