MEN 10716

a telomerase inhibitor; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Osteosarcoma (Osteogenic Sarcoma) 09/01/2002 - "Conversely, MEN 10716 treatment did not appreciably inhibit cell proliferation in the U2-OS telomerase-negative human osteogenic sarcoma cell line. "
2.	Melanoma (Melanoma, Malignant) 09/01/2002 - "When intact JR8 melanoma cells were chronically exposed to the drug (200 microM every other day for 50 days), a marked inhibition (>80%) of the enzyme's catalytic activity was consistently observed starting from day 1. At later points in time, MEN 10716 inhibited melanoma cell proliferation and induced apoptosis. " 09/01/2002 - "Exposure of human melanoma cell extracts to MEN 10716 induced a dose-dependent inhibition of telomerase activity, with an IC50 of 24+/-3 microM. "

1.	Telomerase (Telomerase Reverse Transcriptase)
2.	Enzymes
3.	Cell Extracts