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BIX 645

a p38 MAP kinase inhibitor; Boehringer Ingelheim;

Also Known As:

BIX-645; BIX645

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- BIX 645: 1

Experts

1.	Belosjorow, Sergej: 1 article (08/2002)
2.	Gres, Petra: 1 article (08/2002)
3.	Heusch, Gerd: 1 article (08/2002)
4.	Jansen, Johanna: 1 article (08/2002)
5.	Michel, Martin C: 1 article (08/2002)
6.	Schulz, Rainer: 1 article (08/2002)

Related Diseases

1.	Ischemia 08/15/2002 - "IS reduction by IP was abolished by BIX-645 (26.2+/-6.4 or 25.5+/-4.7) and SB203580 (19.9+/-4.3 or 16.7+/-4.7), given either prior to IP or the sustained ischemia, respectively. " 08/15/2002 - "Pigs received BIX-645 (1 mg/kg, i.v.) or SB203580 (10 microM, i.c.) prior to either IP or the sustained ischemia. " 08/15/2002 - "The supernatant of homogenized myocardial biopsies taken during the sustained ischemia from preconditioned pigs receiving either BIX-645 or SB203580 inhibited the anisomycin-stimulated ATF-2 phosphorylation in cultured Rat1 fibroblasts. "
2.	Infarction (Infarctions) 08/15/2002 - "We have now tested whether the two structurally unrelated p38MAPK-inhibitors, BIX-645 and SB203580, abolished infarct size (IS) reduction by IP in pigs and whether their effects depended on the time of administration. "

Related Drugs and Biologics

1.	Anisomycin
2.	SB 203580