4-hydroxy-3-methyl-2-butenyl diphosphate

a phosphoantigen; structure in first source

Also Known As:

(E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate; (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate; 1-hydroxy-2-methyl-but-2-enyl 4-diphosphate; 1-hydroxy-2-methylbut-2-enyl 4-diphosphate; 4-hydroxydimethylallyl diphosphate; HDMAPP cpd; HMBPP cpd

Networked: 13 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphates: 1942
    - 4-hydroxy-3-methyl-2-butenyl diphosphate: 13

Experts

1.	Chen, Zheng W: 3 articles (11/2020 - 01/2009)
2.	Huang, Dan: 3 articles (11/2020 - 01/2009)
3.	Shen, Ling: 3 articles (11/2020 - 01/2009)
4.	Eberl, Matthias: 3 articles (01/2016 - 04/2007)
5.	Frencher, James: 2 articles (11/2020 - 01/2019)
6.	Qaqish, Arwa: 2 articles (11/2020 - 01/2019)
7.	Shen, Hongbo: 2 articles (11/2020 - 01/2019)
8.	Herrmann, Thomas: 2 articles (01/2020 - 01/2014)
9.	Chen, Crystal Y: 2 articles (01/2019 - 01/2009)
10.	Wang, Richard: 2 articles (01/2019 - 01/2009)

Related Diseases

1.	Infections 01/01/2019 - "Our previous studies demonstrate that Vγ2Vδ2 T cells specific for (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) phosphoantigen are unique in primates as multifunctional effectors of immune protection against TB infection. " 01/01/2017 - "A recent study provides evidence that a specific parasite factor, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, may increase both the attractiveness of infected vertebrates and the susceptibility of mosquitoes to infection." 11/01/2020 - "Vγ2Vδ2 T cells are the sole γδ T-cell subpopulation capable of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathogens during infections. " 12/01/2009 - "Our model incorporates the peculiar innate-like specificity of Vgamma9/Vdelta2 T cells for the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), co-recruitment of monocytes and Vgamma9/Vdelta2 T cells to sites of infection, and their crosstalk, with profound consequences for the initiation of antigen-specific alphabeta T-cell responses. " 01/01/2016 - "By analyzing local and systemic immune responses in peritoneal dialysis patients presenting with acute bacterial peritonitis and monitoring individuals before and during defined infectious episodes, our data show that Vγ9/Vδ2(+) γδ T cells and mucosal-associated invariant T cells accumulate at the site of infection with organisms producing (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and vitamin B2, respectively. "
2.	Neoplasms (Cancer) 05/21/2009 - "Here we have studied the most potent natural phosphoantigen yet identified, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), produced by Eubacteria and Protozoa, and examined its gammadelta T-cell activation and anti-tumor properties. " 11/15/2015 - "Vγ2Vδ2 T cells play important roles in human immunity to pathogens and in cancer immunotherapy by responding to isoprenoid metabolites, such as (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and isopentenyl pyrophosphate. " 01/01/2020 - "These TCRs respond to phosphoantigens (PAg) such as (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), which is found in many pathogens, and isopentenyl pyrophosphate (IPP), which accumulates in certain tumors or cells treated with aminobisphosphonates such as zoledronate. " 01/01/2014 - "Vγ9Vδ2 T cells respond to phosphoantigens (PAg) such as (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), which is produced by many pathogens and isopentenyl pyrophosphate (IPP), which accumulates in certain tumors or cells treated with aminobisphosphonates such as zoledronate. "
3.	Malaria 12/01/2018 - "Vγ9Vδ2 T cells, the dominant γδ T cell subset in human peripheral blood, are stimulated by phosphoantigens, of which (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate, is produced in the apicoplast of malaria parasites. " 09/04/2020 - "This odour-driven manipulation is partly mediated by the gametocyte-specific metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), which induces increased release of select aldehydes and terpenes from red blood cells and results in the enhanced attraction of host-seeking mosquitoes, which are vectors of malaria. "
4.	Tuberculosis (Tuberculoses) 01/15/2009 - "Tuberculosis-induced variant IL-4 mRNA encodes a cytokine functioning as growth factor for (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T cells."
5.	Peritonitis 01/01/2016 - "By analyzing local and systemic immune responses in peritoneal dialysis patients presenting with acute bacterial peritonitis and monitoring individuals before and during defined infectious episodes, our data show that Vγ9/Vδ2(+) γδ T cells and mucosal-associated invariant T cells accumulate at the site of infection with organisms producing (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and vitamin B2, respectively. "

Related Drugs and Biologics

1.	4-hydroxy-3-methylbut-2-enyl pyrophosphate
2.	isopentenyl pyrophosphate (isopentenyl diphosphate)
3.	Terpenes (Terpenoids)
4.	Zoledronic Acid (Zometa)
5.	indolepropanol phosphate (IPP)
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	Cytokines
8.	Interleukin-4 (Interleukin 4)
9.	Messenger RNA (mRNA)
10.	Riboflavin (Vitamin B2)

Related Therapies and Procedures

1.	Peritoneal Dialysis
2.	Immunotherapy