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bisindolylmaleimide IX

potentiator of TNF receptor family-mediated cell death; inhibits transcription

Also Known As:

Bis IX

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cohen, Michael B: 2 articles (05/2003 - 09/2002)
2.	Rokhlin, Oskar W: 2 articles (05/2003 - 09/2002)
3.	Ao, Junping: 1 article (10/2016)
4.	Azam, Mohammad: 1 article (10/2016)
5.	Habib, Samy L: 1 article (10/2016)
6.	Jia, Deyong: 1 article (10/2016)
7.	Jia, Hao: 1 article (10/2016)
8.	Li, Baojie: 1 article (10/2016)
9.	Li, Jia: 1 article (10/2016)
10.	Liu, Huijuan: 1 article (10/2016)

Related Diseases

1.	Neoplasms (Cancer) 10/25/2016 - "Mouse cancer model experiments showed that Bisindolylmaleimide IX, at doses that show little side effect, was effective in treating leukemia-like disorders induced by BCR-ABL or T315I BCR-ABL, and prolonged the lifespan of these model mice. " 05/01/2003 - "In conclusion, Bis IX could be used as a drug to facilitate apoptosis of cancer cells that are resistant to treatment with death-inducing ligands as well as a valuable tool to discern the factors that mediate resistance to different death-inducing ligands."
2.	Leukemia 10/25/2016 - "Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia." 10/25/2016 - "Mouse cancer model experiments showed that Bisindolylmaleimide IX, at doses that show little side effect, was effective in treating leukemia-like disorders induced by BCR-ABL or T315I BCR-ABL, and prolonged the lifespan of these model mice. "
3.	Colonic Neoplasms (Colon Cancer) 04/01/2008 - "Bisindolylmaleimide IX facilitates extrinsic and initiates intrinsic apoptosis in TNF-alpha-resistant human colon adenocarcinoma COLO 205 cells."
4.	Carcinoma (Carcinomatosis) 09/06/2002 - "Bis IX induced p53 accumulation in LNCaP (lymph node carcinoma of prostate), which expresses wild-type p53 that was not accompanied by the induction of p53-responsive genes, p21/WAF1, and Mdm2. " 09/06/2002 - "We investigated the effect of four Bis derivatives (I, II, VIII, and IX) in human prostatic carcinoma cell lines and found that Bis IX was the most potent inducer of apoptosis under simultaneous treatment with TNF-alpha, agonistic anti-Fas monoclonal antibody, and TNF-related apoptosis-inducing ligand (TRAIL). "
5.	Oncogene Addiction 10/25/2016 - "Thus, Bisindolylmaleimide IX presents a novel drug candidate to treat drug-resistant CML via activating BCR-ABL-dependent genotoxic stress response and inhibiting the oncogene addiction pathway activated by BCR-ABL." 10/25/2016 - "Cells positive for BCR-ABL or drug-resistant T315I BCR-ABL also display increased cytotoxicity since Bisindolylmaleimide IX inhibits B-Raf and the downstream oncogene addiction pathway. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	TNF-Related Apoptosis-Inducing Ligand
3.	Ligands
4.	anti-Fas monoclonal antibody