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1- (4- (4- (3,3- dibutyl- 7- (dimethylamino)- 2,3,4,5- tetrahydro- 4- hydroxy- 1,1- dioxido- 1- benzothiepin- 5- yl)phenoxy)butyl)- 4- aza- 1- azoniabicyclo(2.2.2)octane

inhibits the ileal apical sodium-codependent bile acid transporter

Also Known As:

SC 435; SC-435; SC435

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
Organic Chemicals: 133
- Aza Compounds: 3
  - Azabicyclo Compounds
    - Tropanes: 1
      - 1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane: 6

Experts

1.	Dawson, Paul A: 2 articles (01/2020 - 01/2016)
2.	Karpen, Saul J: 2 articles (01/2020 - 01/2016)
3.	Rao, Anuradha: 2 articles (01/2020 - 01/2016)
4.	Napawan, Nida: 2 articles (05/2008 - 09/2003)
5.	Butteiger, Dustie N: 2 articles (12/2003 - 09/2003)
6.	Keller, Bradley T: 2 articles (12/2003 - 09/2003)
7.	Gumber, Sanjeev: 1 article (01/2020)
8.	van de Peppel, Ivo P: 1 article (01/2020)
9.	Huang, Fengjie: 1 article (11/2018)
10.	Jia, Wei: 1 article (11/2018)

Related Diseases

1.	Atherosclerosis 09/01/2003 - "Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE-/- mice by SC-435." 12/01/2003 - "SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs." 05/01/2008 - "The dKO mice were similarly treated with SC-435 (0.01% (w/w)), an apical sodium codependent bile acid transporter (ASBT) inhibitor, that blocks intestinal absorption of bile acids, lowers plasma cholesterol in animals, and reduces aortic root atherosclerosis in apoE KO mice. "
2.	Non-alcoholic Fatty Liver Disease 01/01/2020 - "We previously reported that interruption of the enterohepatic circulation of bile acids using a non-absorbable apical sodium-dependent bile acid transporter inhibitor (ASBTi; SC-435) reduced the development of NAFLD in high fat diet fed mice. "
3.	Liver Failure 11/01/2018 - "Inhibition of intestinal ASBT with SC-435 can effectively remove neurotoxic BAs and ammonia from the bloodstream and thus, mitigate liver and brain injuries resulting from liver failure."
4.	Fatty Liver 01/01/2016 - "We hypothesized that interruption of the enterohepatic BA circulation using a luminally restricted apical sodium-dependent BA transporter (ASBT) inhibitor (ASBTi; SC-435) would modify signaling in the gut-liver axis and reduce steatohepatitis in high-fat diet (HFD)-fed mice. "
5.	Brain Injuries (Brain Injury) 11/01/2018 - "Inhibition of intestinal ASBT with SC-435 can effectively remove neurotoxic BAs and ammonia from the bloodstream and thus, mitigate liver and brain injuries resulting from liver failure."

Related Drugs and Biologics

1.	Sodium
2.	Bile Acids and Salts (Bile Acids)
3.	Cholesterol
4.	Apolipoproteins E (ApoE)
5.	bile acid binding proteins
6.	Ammonia
7.	sodium-bile acid cotransporter