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2- (1- (3- dimethylaminopropyl)- 5- methoxyindol- 3- yl)- 3- (1H- indol- 3- yl)maleimide

Subscribe to New Research on 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide

Also Known As:

Gö6983

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Pyrroles: 16
      - Maleimides: 4
        2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide: 7
- 2-Ring Heterocyclic Compounds
  - Indoles: 95
    - 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide: 7
Organic Chemicals: 58
- Carboxylic Acids: 83
  - Acyclic Acids
    - Dicarboxylic Acids: 76
      - Maleates: 3
        Maleimides: 4
        2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide: 7
- Imides: 16
  - Maleimides: 4
    - 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide: 7

Experts

1.	Shultz, Michael D: 1 article (05/2012)
2.	Chalfant, Charles E: 1 article (05/2012)
3.	Mba, Mba-Uzoma U: 1 article (05/2012)
4.	Vu, Ngoc: 1 article (05/2012)
5.	Shapiro, Brian A: 1 article (05/2012)
6.	Shultz, Jacqueline C: 1 article (05/2012)
7.	Wu, Anshi: 1 article (01/2011)
8.	Wu, Jing: 1 article (01/2011)
9.	Fang, Li: 1 article (01/2011)
10.	Mu, Xiaobo: 1 article (01/2011)

Related Diseases

1.	Adenocarcinoma 10/01/2003 - "In the present study, we investigated the effects of several selective protein kinase C (PKC) inhibitors (Gö6976, Gö6983, bisindolylmaleimide I, and rottlerin) in combination with conventional anticancer drugs on apoptosis and long-term anchorage-independent growth of both parental and Bcl-2-overexpressing mammary adenocarcinoma MTLn3 cells. "
2.	Plasmacytoma 04/01/2002 - "The effect of chemical blockade of PKC with Gö6976 and Gö6983 on proliferation and MAPK activity in IL-6-dependent plasmacytoma cells."
3.	Pain (Aches) 01/01/2011 - "Intrathecal injection of a calcium-dependent protein kinase (PKC) inhibitor, Gö6983 (10 μM), significantly reversed the incision-mediated over-expression of pGluR1-Ser-831 in spinal dorsal horn at 3 h after incision and decreased the cumulative pain scores as well. "
4.	Neoplasms (Cancer) 10/01/2009 - "These results suggest that Gö6983 functions as an NK cell activating molecule (NKAM); this NKAM is a novel anti-cancer and anti-metastasis drug candidate because it enhances NK cytotoxicity against cancer cells in vivo as well as in vitro." 10/01/2009 - "Most importantly, administration of Gö6983 effectively inhibited pulmonary tumor metastasis in mice in a dose-dependent manner. " 10/01/2009 - "Up-regulation of NCRs and death ligands on NK cells by Gö6983 resulted in a significant enhancement of NK cytotoxicity against various cancer cell lines. "
5.	Neoplasm Metastasis (Metastasis) 10/01/2009 - "These results suggest that Gö6983 functions as an NK cell activating molecule (NKAM); this NKAM is a novel anti-cancer and anti-metastasis drug candidate because it enhances NK cytotoxicity against cancer cells in vivo as well as in vitro." 10/01/2009 - "Most importantly, administration of Gö6983 effectively inhibited pulmonary tumor metastasis in mice in a dose-dependent manner. "

Related Drugs and Biologics

1.	Protein Kinase C
2.	rottlerin
3.	bisindolylmaleimide I
4.	Small Interfering RNA (siRNA)
5.	Messenger RNA (mRNA)
6.	Phosphotransferases (Kinase)
7.	Ligands
8.	Ro 32-0432
9.	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- one
10.	calcium-dependent protein kinase

Related Therapies and Procedures

1.	Spinal Injections