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SB202494

has no known p38 MAPK inhibitory effects

Also Known As:

4-ethyl-2-(4-methoxyphenyl)-5-(4-pyridyl)-1H-imidazole; SB 202474; SB 202494; SB-202474; SB-202494; SB202474

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - SB202494: 3

Experts

1.	Liu, Changjiang: 1 article (01/2018)
2.	Yang, Min: 1 article (01/2018)
3.	Zeng, Li: 1 article (01/2018)
4.	Zhang, Pei: 1 article (01/2018)
5.	Hara, A: 1 article (03/2010)
6.	Hayashi, K: 1 article (03/2010)
7.	Hoshino, T: 1 article (03/2010)
8.	Ishii, T: 1 article (03/2010)
9.	Nishimura, B: 1 article (03/2010)
10.	Oikawa, K: 1 article (03/2010)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 10/01/2007 - "Next, the pathophysiological roles of p38 MAPK activation were investigated in differentiated gastric cancer cell lines MKN7 and MKN28 and poorly differentiated gastric cancer cell lines KATO-III and MKN45 cells by incubating with specific p38 inhibitor SB203580 or inactivating analog SB202474. "
2.	Hypothyroidism 01/01/2018 - "To verify our hypothesis that the MAPK pathway may function significantly in triclosan-induced hypothyroidism, Sprague-Dawley rats were gavaged with triclosan for 31 consecutive days; Nthy-ori 3-1 cells were treated with triclosan in the presence/absence of NAC, inhibitors (SB203580 and SB202474), or TRHr siRNA. "
3.	Ototoxicity 03/17/2010 - "The inhibitors SB202190 and SB203580 but not the inactive analogue SB202474 dose-dependently decreased the auditory threshold shift and outer hair cell loss induced by acoustic overexposure, suggesting the involvement of p38 MAPK in ototoxicity. "

Related Drugs and Biologics

1.	SB 203580
2.	p38 Mitogen-Activated Protein Kinases
3.	Small Interfering RNA (siRNA)
4.	Triclosan (pHisoHex)
5.	4- (4- fluorophenyl)- 2- (4- hydroxyphenyl)- 5- (4- pyridyl)imidazole