tiarellic acid

new 27-carboxylic lupane-type triterpene from Tiarella polyphylla (Saxifragaceae); structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Carcinogenesis 09/01/2008 - "Regulation of TM4SF5-mediated tumorigenesis through induction of cell detachment and death by tiarellic acid."
2.	Respiratory Hypersensitivity 01/01/2012 - "Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma." 01/01/2012 - "In the current research, we studied the anti-inflammatory and anti-asthmatic effects of tiarellic acid (TA) isolated from Tiarella polyphylla, based on asthmatic parameters, such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness (AHR), reactive oxygen species (ROS) and mucus hypersecretion, in an ovalbumin (OVA)-sensitized/challenged mouse model. "
3.	Inflammation (Inflammations) 01/01/2012 - "Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma."
4.	Eosinophilia 01/01/2012 - "In the current research, we studied the anti-inflammatory and anti-asthmatic effects of tiarellic acid (TA) isolated from Tiarella polyphylla, based on asthmatic parameters, such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness (AHR), reactive oxygen species (ROS) and mucus hypersecretion, in an ovalbumin (OVA)-sensitized/challenged mouse model. "
5.	Asthma (Bronchial Asthma) 01/01/2012 - "Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma."

1.	Anti-Asthmatic Agents (Antiasthmatic Drugs)
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Cytokines
4.	Ovalbumin
5.	Immunoglobulin E (IgE)