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PN 7051

inhibits tissue factor-dependent coagulation and thrombus formation; structure in first source

Also Known As:

PN-7051; PN7051

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - PN 7051: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - PN 7051: 2

Experts

1.	Orning, Lars: 2 articles (05/2007 - 01/2002)
2.	Sakariassen, Kjell S: 2 articles (05/2007 - 01/2002)
3.	Agner, Erik: 1 article (01/2002)
4.	Engebretsen, May: 1 article (01/2002)
5.	Fischer, Peter M: 1 article (01/2002)
6.	Hu, Chih-Kao: 1 article (01/2002)
7.	Husbyn, Mette: 1 article (01/2002)
8.	Llinas, Miguel: 1 article (01/2002)
9.	Orvim, Una: 1 article (01/2002)
10.	Petersen, Lizette B: 1 article (01/2002)

Related Diseases

1.

Thrombosis (Thrombus)

05/01/2007 - "This review focuses on the validation of the principal initiator of human coagulation, the tissue factor (TF)/coagulation factor (F)VIIa complex, as an antithrombotic target, as well as on the discovery of a cyclic pentapeptide (PN7051), which dose-dependently inhibits TF/FVIIa-induced coagulation and thrombus formation. "
01/01/2002 - "Fibrin deposition, platelet-fibrin adhesion, platelet-thrombus formation, and thrombin-antithrombin complex formation were all inhibited by PN7051 at IC50 values between 0.3 and 0.7 mM. The cyclic peptide is a non-competitive inhibitor of FX activation with no significant active-site effects on FXa or FVIIa, indicating it affects FVII/TF/FX complex formation and function. "

Related Drugs and Biologics

1.	Thromboplastin (Tissue Factor)
2.	Cyclic Peptides
3.	Fibrin
4.	Blood Coagulation Factors (Coagulation Factor)
5.	antithrombin III-protease complex