sophoranone

a flavonoid compound with isoprenoid side chains; extracted from a traditional Chinese medicine Shan Dou Gen, isolated from the roots of Sophora subprostrata; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bae, Soo Hyeon: 1 article (01/2015)
2.	Bae, Soo Kyung: 1 article (01/2015)
3.	Choi, Woong-Kee: 1 article (01/2015)
4.	Jang, Soo Min: 1 article (01/2015)
5.	Kang, Minseok: 1 article (01/2015)
6.	Kim, Doyun: 1 article (01/2015)
7.	Min, Jee Sun: 1 article (01/2015)
8.	Park, Jung Bae: 1 article (01/2015)
9.	Ryu, Keun Ho: 1 article (01/2015)
10.	Yoo, Hunseung: 1 article (01/2015)

Related Diseases

1.	Ulcer 11/01/1978 - "The anti-ulcer effect of sophoranone was approximately the same as that of Fr. " 11/01/1978 - "The anti-ulcer effect of sophoradin was relatively potent in comparison with that of sophoranone and/or Fr. "
2.	Stomach Neoplasms (Stomach Cancer) 06/20/2002 - "Sophoranone inhibited cell growth and induced apoptosis in various lines of cells from human solid tumors, with 50% inhibition of growth of human stomach cancer MKN7 cells at 1.2 +/- 0.3 microM. "
3.	Neoplasms (Cancer) 06/20/2002 - "Sophoranone inhibited cell growth and induced apoptosis in various lines of cells from human solid tumors, with 50% inhibition of growth of human stomach cancer MKN7 cells at 1.2 +/- 0.3 microM. "
4.	Leukemia 06/20/2002 - "We purified the compound that induced apoptosis in human leukemia cells and identified it as sophoranone. " 06/20/2002 - "Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores." 06/20/2002 - "The growth-inhibitory and apoptosis-inducing activities of sophoranone for leukemia U937 cells were very much stronger than those of other flavonoids, such as daidzein, genistein and quercetin. "
5.	Asthma (Bronchial Asthma) 01/01/2015 - "1. SKI3301, a standardized dried 50% ethanolic extracts of Sophora tonkinensis, contains four marker compounds (trifolirhizin, TF; (-)-maackiain, Maack; (-)-sophoranone, SPN, and (2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran, ABF), is being developed as an herbal medicine for the treatment of asthma in Korea. "

Related Drugs and Biologics

1.	Genistein
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Quercetin
4.	Flavonoids
5.	trifolirhizin
6.	daidzein
7.	inermin

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)