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ostreolysin

purified from the fruiting bodies of the edible mushrooms Pleurotus ostreatus; amino acid sequence in first source

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Hemolysin Proteins: 1059
        ostreolysin: 6
  - Fungal Proteins: 47
    - ostreolysin: 6

Experts

1.	Resnik, Nataša: 2 articles (01/2015 - 01/2012)
2.	Sepčić, Kristina: 2 articles (01/2015 - 01/2012)
3.	Veranič, Peter: 2 articles (01/2015 - 01/2012)
4.	Macek, Peter: 2 articles (03/2007 - 08/2005)
5.	Graeve, Lutz: 1 article (04/2017)
6.	Hadar, Yitzhak: 1 article (04/2017)
7.	Nimri, Lili: 1 article (04/2017)
8.	Peri, Irena: 1 article (04/2017)
9.	Salame, Tomer M: 1 article (04/2017)
10.	Schwartz, Betty: 1 article (04/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "In the present study, a raft marker, ostreolysin, revealed the enrichment of cholesterol-sphingomyelin membrane nanodomains along ICNs in a T24 (malignant) urothelial cancer cell line. " 01/01/2015 - "Highly Selective Anti-Cancer Activity of Cholesterol-Interacting Agents Methyl-β-Cyclodextrin and Ostreolysin A/Pleurotolysin B Protein Complex on Urothelial Cancer Cells."
2.	Neuroblastoma 04/01/2015 - "Effect of the ostreolysin A/pleurotolysin B pore-forming complex on neuroblastoma cell morphology and intracellular Ca²⁺ activity."
3.	Infections 03/01/2007 - "Based on sequence similarities of ostreolysin and Asp-hemolysin, their comparable cytolytic effects towards different cells, and similar signs of intoxication in experimental animals, our results indicate that Asp-hemolysin might be considered as a possible virulence factor of Aspergillus fumigatus during the infection of bone and cartilage."
4.	Hemolysis 08/23/2005 - "pH-induced and thermally induced unfolding of ostreolysin was studied by means of CD, UV absorption, and intrinsic tryptophan fluorescence to characterize conformational transitions associated with its functional properties, i.e., binding to lipid membranes, pore forming activity on lipid vesicles, and hemolysis. "
5.	Colonic Neoplasms (Colon Cancer) 04/25/2017 - "Ostreolysin (Oly) is a protein found in the mushroom Pleurotus ostreatus, and we have produced a recombinant version of this protein (rOly).We measured the viability of several colon cancer cells treated with rOly. "

Related Drugs and Biologics

1.	Cholesterol
2.	Sphingomyelins
3.	Proteins (Proteins, Gene)
4.	Virulence Factors (Pathogenicity Factors)
5.	Tryptophan (L-Tryptophan)
6.	Lipids
7.	Hemolysin Proteins (Hemolysins)
8.	Cyclodextrins