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N- (2,6- dichlorobenzoyl)- 4- (2',6'- bismethoxyphenyl)phenylalanine

TR-14035 is the (L)-isomer; an antagonist of both alpha4beta1 and beta7 integrins; structure in first source

Also Known As:

TR 14035; TR-14035; TR14035

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Essential Amino Acids: 1152
    - Phenylalanine: 4090
      - N-(2,6-dichlorobenzoyl)-4-(2',6'-bismethoxyphenyl)phenylalanine: 2
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 467
      - Phenylalanine: 4090
        N-(2,6-dichlorobenzoyl)-4-(2',6'-bismethoxyphenyl)phenylalanine: 2

Experts

1.	Connolly, Patrick J: 1 article (01/2021)
2.	Fang, Angela: 1 article (01/2021)
3.	Shao, Jiasheng: 1 article (01/2021)
4.	Veazey, Ronald S: 1 article (01/2021)
5.	Wang, Xiaolei: 1 article (01/2021)
6.	Xu, Huanbin: 1 article (01/2021)
7.	Ziani, Widade: 1 article (01/2021)
8.	Alfón, José: 1 article (03/2006)
9.	Cortijo, Julio: 1 article (03/2006)
10.	Gómez, Luis A: 1 article (03/2006)

Related Diseases

1.	Virus Diseases (Viral Diseases) 01/01/2021 - "In this study, we investigated the efficacy of prophylactic integrin blockade (α4β7 antibody or α4β7/α4β1 dual antagonist TR-14035) on viral infection, as well as dissemination and seeding of viral reservoirs in systemic and lymphoid compartments post-SIV inoculation. "
2.	Disease Progression 01/01/2021 - "Surprisingly, TR-14035 administration in acute SIV infection resulted in consistently higher viremia and more rapid disease progression. "
3.	Viremia 01/01/2021 - "Surprisingly, TR-14035 administration in acute SIV infection resulted in consistently higher viremia and more rapid disease progression. "
4.	Infections 01/01/2021 - "Surprisingly, TR-14035 administration in acute SIV infection resulted in consistently higher viremia and more rapid disease progression. "
5.	Asthma (Bronchial Asthma) 03/01/2006 - "We investigated the effects of TR14035, a small molecule, alpha(4)beta(1)/alpha(4)beta(7) dual antagonist, in a rat model of allergic asthma. " 03/01/2006 - "In conclusion, TR14035, by acting on alpha(4)beta(1) and alpha(4)beta(7) integrins, is an orally active inhibitor of airway leukocyte recruitment and hyper-responsiveness in animal models with potential interest for the treatment of asthma."

Related Drugs and Biologics

1.	Integrins