lamellarin D

10/15/2010 - "In this study, proton NMR spectroscopy-based metabolomics was applied to unravel biochemical disorders induced in human MCF7 breast cancer cells by 3 lead candidate anticancer MNPs: ascididemin (Asc), lamellarin-D (Lam-D), and kahalalide F (KF). "

12/01/2009 - "Thus, lamellarin D constitutes a new proapoptotic agent that may bypass certain forms of apoptosis resistance that occur in tumor cells."
03/15/2006 - "Altogether, this work reinforces the pharmacologic interest of the lamellarins and defines lamellarin D as a lead in the search for treatments against chemoresistant cancer cells."
03/15/2006 - "Using complementary cell-based assays, we provide evidence that lamellarin D acts on cancer cell mitochondria to induce apoptosis. "
01/01/2019 - "The activities of BBPIs were higher than those of lamellarin D and camptothecin; they showed potent and selective antiproliferative activity in the panel of 39 human cancer cell lines established by Japanese Foundation for Cancer Research. "
02/19/2015 - "The lead compound in the family is lamellarin D, characterized as a potent inhibitor of both nuclear and mitochondrial topoisomerase I but also capable of directly interfering with mitochondria to trigger cancer cell death. "

01/01/2014 - "Inhibition effects of lamellarin D on human leukemia K562 cell proliferation and underlying mechanisms."
12/01/2009 - "Upon lamellarin D exposure, Fas and Fas-L expression was not modified in leukemia cells. "
12/01/2009 - "Lamellarin D promoted nuclear apoptosis in leukemia cells without prominent cell cycle arrest. "
03/15/2006 - "Using a reliable real-time flow cytometric monitoring of Deltapsi(m) and swelling of mitochondria isolated from leukemia cells, we show that lamellarin D has a direct MPT-inducing effect. "
12/01/2009 - "Moreover, leukemia cells deficient in caspase-8 or Fas-associated protein with death domain underwent apoptosis through the typical mitochondrial apoptotic cascade, indicating that cell death induced by lamellarin D was independent of the extrinsic apoptotic pathway. "

04/28/2005 - "Lamellarin D (LAM-D) is a marine alkaloid endowed with potent cytotoxic activities against various tumor cells, in particular human prostate cancer cells and leukemia cells. "

08/01/2014 - "Poisoning of mitochondrial topoisomerase I by lamellarin D."