araguspongine C

from the marine sponge Xestospongia sp.; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Breast Neoplasms (Breast Cancer) 01/08/2015 - "Remarkably, araguspongine C treatment resulted in the suppression of PI3K/Akt/mTOR signaling cascade in breast cancer cells undergoing autophagy. " 01/08/2015 - "Interestingly, araguspongine C-induced autophagic cell death in HER2-overexpressing BT-474 breast cancer cells was characterized by vacuole formation and upregulation of autophagy markers including LC3A/B, Atg3, Atg7, and Atg16L. " 01/08/2015 - "Araguspongine C inhibited the proliferation of multiple breast cancer cell lines in vitro in a dose-dependent manner. " 01/08/2015 - "Araguspongine C induces autophagic death in breast cancer cells through suppression of c-Met and HER2 receptor tyrosine kinase signaling." 01/08/2015 - "In conclusion, results of this study are the first to reveal the potential of araguspongine C as an inhibitor to receptor tyrosine kinases resulting in the induction of autophagic cell death in breast cancer cells. "
2.	Neoplasms (Cancer) 02/01/2019 - "Both araguspongine C (1) and meso-araguspongine C (2) exhibited great cytotoxic activity towards HepG-2, HL-60, LU-1, MCF-7, and SK-Mel-2 human cancer cells (IC50 in the range of 0.43-1.02 μM). "

1.	Phosphotransferases (Kinase)
2.	tyrosine receptor (receptor, tyrosine)
3.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)