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UGT1A8 UDP-glucuronosyltransferase (UGT1A8)

induced by 3-methylcholanthene in rat hepatoma cells
Also Known As:
UGT1A8; UDP-glucuronosyltransferase, UGT1A8
Networked: 13 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Wang, Xi: 2 articles (09/2020 - 01/2018)
2. Zhang, Bei: 2 articles (09/2020 - 01/2018)
3. Zhao, Feng: 2 articles (09/2020 - 01/2018)
4. Zhou, Xueyan: 2 articles (09/2020 - 01/2018)
5. Jin, Feng: 1 article (12/2021)
6. Xu, Dong: 1 article (12/2021)
7. Zhang, Yiqi: 1 article (12/2021)
8. Lai, Ran: 1 article (09/2020)
9. Wang, Yan: 1 article (09/2020)
10. Zhang, Jingbo: 1 article (09/2020)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
09/01/2011 - "No UGT polymorphism was associated with breast cancer recurrence in either the ER(+)/TAM(+) or ER(-)/TAM(-) groups [in the ER(+)/TAM(+) group, compared with two normal alleles: adjusted OR for two UGT2B15*2 variant alleles = 1.0 (95% CI, 0.70-1.5); adjusted OR for two UGT2B7*2 variant alleles = 0.96 (95% CI, 0.65-1.4); adjusted OR for one or two UGT1A8*3 variant alleles = 0.95 (0.49-1.9)]. "
09/01/2011 - "We measured the association between functional polymorphisms in key UGTs (UGT2B15*2, UGT2B7*2, and UGT1A8*3) and the recurrence rate among breast cancer survivors. "
07/01/2013 - "Potential influence of UGT1A8 genotype on osteoporosis and breast cancer treatment outcome."
01/01/2018 - "Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer. "
12/09/2021 - "The study identified several hub genes in the PPI network that may be involved in the development of TAM resistance of breast cancer, including signal transducer and activator of transcription 1 (STAT1), estrogen receptor alpha (ESR1), fibronectin1 (FN1), cytochrome P4501B1 (CYP1B1), AKR1C1, AKR1C2, AKR1C3 and uridine diphosphate glucuronosyltransferase (UGT) 1A family genes (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10). "
2. Schizophrenia (Dementia Praecox)
3. Neoplasms (Cancer)
4. Endometrial Neoplasms (Endometrial Cancer)
5. Colorectal Neoplasms (Colorectal Cancer)

Related Drugs and Biologics

1. bilirubin uridine-diphosphoglucuronosyl transferase 1A10 (UGT1A10)
2. Glucuronosyltransferase (UDP Glucuronosyltransferase)
3. Cytochrome P-450 CYP1B1
4. STAT1 Transcription Factor
5. Estrogen Receptor alpha
6. Raloxifene Hydrochloride (Evista)
7. Uridine Diphosphate (UDP)
8. Antipsychotic Agents (Antipsychotics)
9. Messenger RNA (mRNA)
10. Estrogens (Estrogen)