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carmustine with prolifeprosan 20

a lipid soluble agent capable of crossing the BBB and achiving potentially tumoricidal concentrations

Also Known As:

polifeprosan 20 with carmustine

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Nitrosourea Compounds: 21
      - Carmustine: 2249
        carmustine with prolifeprosan 20: 4
- Nitroso Compounds: 446
  - Nitrosourea Compounds: 21
    - Carmustine: 2249
      - carmustine with prolifeprosan 20: 4

Experts

1.	Olivi, Alessandro: 2 articles (10/2008 - 02/2007)
2.	Kleinberg, Lawrence: 1 article (01/2016)
3.	Glick, Jorie A: 1 article (01/2010)
4.	Graham, Robert S: 1 article (01/2010)
5.	Voils, Stacy A: 1 article (01/2010)
6.	Attenello, Frank J: 1 article (10/2008)
7.	Bohan, Eileen: 1 article (10/2008)
8.	Brem, Henry: 1 article (10/2008)
9.	Datoo, Ghazala: 1 article (10/2008)
10.	McGirt, Matthew J: 1 article (10/2008)

Related Diseases

1.	Glioma (Gliomas) 10/01/2008 - "Gliadel (polifeprosan 20 with carmustine [BCNU] implant) is commonly used for local delivery of BCNU to high-grade gliomas after resection and is associated with increased survival. " 02/01/2007 - "Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial."
2.	Brain Neoplasms (Brain Tumor) 02/01/2007 - "Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial."
3.	Neoplasms (Cancer) 01/01/2016 - "Polifeprosan 20 with carmustine (GLIADEL®) polymer implant wafer is a biodegradable compound containing 3.85% carmustine (BCNU, bischloroethylnitrosourea) implanted in the brain at the time of planned tumor surgery, which then slowly degrades to release the BCNU chemotherapy directly into the brain thereby bypassing the blood-brain barrier. "
4.	Meningitis 01/01/2010 - "To report a case of Candida meningitis post Gliadel wafer (polifeprosan 20 with carmustine implant) placement successfully treated with the combination of intrathecal and intravenous amphotericin B. "

Related Drugs and Biologics

1.	O(6)-benzylguanine
2.	Carmustine (FIVB)
3.	poliferprosan 20 drug combination carmustine (Gliadel)
4.	Polymers
5.	Amphotericin B (Amphotericin)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)