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amooranin

isolated from Amoora rohituka; structure in first source

Also Known As:

25-hydroxy-3-oxoolean-12-en-28-oic acid

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - amooranin: 8

Experts

1.	Rabi, Thangaiyan: 4 articles (06/2008 - 07/2003)
2.	Bishayee, Anupam: 3 articles (08/2015 - 12/2013)
3.	Melnick, Steven J: 3 articles (11/2006 - 07/2003)
4.	Ramachandran, Cheppail: 3 articles (11/2006 - 07/2003)
5.	Bhatia, Deepak: 2 articles (12/2014 - 12/2013)
6.	Mandal, Animesh: 2 articles (12/2014 - 12/2013)
7.	Banerjee, Sipra: 2 articles (06/2008 - 01/2007)
8.	Alamo, Arturo: 2 articles (11/2006 - 08/2003)
9.	Escalon, Enrique: 2 articles (11/2006 - 08/2003)
10.	Fonseca, Hugo B: 2 articles (08/2003 - 07/2003)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2007 - "Novel triterpenoid 25-hydroxy-3-oxoolean-12-en-28-oic acid induces growth arrest and apoptosis in breast cancer cells." 08/01/2003 - "Novel drug amooranin induces apoptosis through caspase activity in human breast carcinoma cell lines." 06/01/2008 - "The present study first investigates that a novel triterpenoid Methyl 25-Hydroxy-3-oxoolean-12-en-28-oate (AMR-Me) derived from 25-Hydroxy-3-oxoolean-12-en-28-oic acid (AMR) is a potent inhibitor of cell growth by inducing human breast cancer MCF-7 cells to undergo apoptosis. "
2.	Carcinogenesis 12/01/2014 - "Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis." 12/01/2013 - "Simultaneous disruption of estrogen receptor and Wnt/β-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland carcinogenesis in rats."
3.	Neoplasms (Cancer) 08/01/2015 - "A methyl derivative natural triterpenoid amooranin (methyl-25-hydroxy-3-oxoolean-12-en-28-oate, AMR-Me) has been found to possess antiproliferative, proapoptotic, and antiinflammatory effects against established tumor cells. " 12/01/2014 - "Methyl-amooranin (methyl-25-hydroxy-3-oxoolean-12-en-28-oate, AMR-Me), a novel synthetic oleanane triterpenoid, reduced the incidence and burden of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats through antiproliferative and proapoptotic effects. "
4.	Carcinoma (Carcinomatosis) 11/15/2006 - "Anticancer effects of amooranin in human colon carcinoma cell line in vitro and in nude mice xenografts." 11/15/2006 - "Amooranin (AMR), a natural triterpenoid drug isolated and characterized from Amoora rohituka stem bark, is cytotoxic to SW620 human colon carcinoma cell line with an IC(50) value of 2.9 microg/ml. This novel compound caused depolarization of mitochondrial membrane and decrease of membrane potential, indicating initial signal of apoptosis induction. " 07/20/2003 - "Amooranin (AMR), a plant terpenoid, isolated from Amoora rohituka, was investigated for its ability to overcome multidrug resistance in human leukemia and colon carcinoma cell lines. " 07/20/2003 - "Novel plant triterpenoid drug amooranin overcomes multidrug resistance in human leukemia and colon carcinoma cell lines."
5.	Leukemia 07/20/2003 - "Amooranin (AMR), a plant terpenoid, isolated from Amoora rohituka, was investigated for its ability to overcome multidrug resistance in human leukemia and colon carcinoma cell lines. " 07/20/2003 - "Novel plant triterpenoid drug amooranin overcomes multidrug resistance in human leukemia and colon carcinoma cell lines."

Related Drugs and Biologics

1.	Triterpenes
2.	methyl 25-hydroxy-3-oxoolean-12-en-28-oate
3.	Catenins
4.	Caspases
5.	9,10-Dimethyl-1,2-benzanthracene
6.	Terpenes (Terpenoids)
7.	Estrogen Receptors
8.	oleanane

Related Therapies and Procedures

1.	Chemoprevention