HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

carboxyphenylglycine

structure in first source

Also Known As:

CPG cpd

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - carboxyphenylglycine: 9

Experts

1.	Dąbrowska-Bouta, Beata: 1 article (01/2013)
2.	Strużyńska, Lidia: 1 article (01/2013)
3.	Sulkowski, Grzegorz: 1 article (01/2013)
4.	Moreira, Thiago S: 1 article (10/2011)
5.	Takakura, Ana C: 1 article (10/2011)

Related Diseases

1.	Tetanus 11/01/1995 - "The mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine [(+)MCPG] did not convert a subthreshold tetanus into a suprathreshold tetanus, nor did (+)MCPG have any effect on the small amount of LTP that was generated by a just suprathreshold tetanus. " 11/01/1993 - "The specific mGluR antagonist (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), applied at a concentration of 250 or 500 microM, reduced the size of the Ca2+ transient whilst either producing a small reduction or, more commonly, having no effect on the synaptic current evoked by the tetanus. "
2.	Status Epilepticus (Complex Partial Status Epilepticus) 03/01/2023 - "The mGluR1 agonist (RS)-3,5-dihydroxyphenylglycine injected intracerebroventricularly increased the sensitivity and severity of pentylenetetrazole-induced status epilepticus, whereas application of the mGluR1 antagonist (+)-2-methyl-4-carboxyphenylglycine (LY367385) alleviated the severity of pentylenetetrazole-induced status epilepticus. "
3.	Ischemia 02/01/1999 - "(+)-2-Methyl-4-carboxyphenylglycine (LY367385), a potent and selective antagonist of mGlu1a metabotropic glutamate receptors, was neuroprotective in the following in vitro and in vivo models of excitotoxic death: (i) mixed cultures of murine cortical cells transiently exposed to N-methyl-D-aspartate (NMDA); (ii) rats monolaterally infused with NMDA into the caudate nucleus; and (iii) gerbils subjected to transient global ischemia. "
4.	Hypoglycemia (Reactive Hypoglycemia) 05/01/1994 - "The metabotropic glutamate receptor antagonist (+)-alpha-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia."
5.	Hypercapnia 10/01/2011 - "Bilateral injection of the non-NMDA receptor antagonist 6,7-dinitro-quinoxaline-2,3-dione (DNQX; 100 mm in 50 nl) and the metabotropic receptor antagonist (+/-)-α-methyl-4-carboxyphenylglycine (MCPG; 100 mm in 50 nl) in the RTN did not affect sympathoexcitatory responses induced by hypercapnia. "

Related Drugs and Biologics

1.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	metabotropic glutamate receptor type 1
4.	alpha-methyl-4-carboxyphenylglycine
5.	N-Methylaspartate (NMDA)
6.	Pentylenetetrazole (Metrazol)
7.	Memantine (Namenda)
8.	Amantadine (Aman)
9.	Acids
10.	FG 9041 (DNQX)