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DB358

structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - DB358: 1
  - Thiophenes: 257
    - DB358: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - DB358: 1

Experts

1.	Bailly, C: 1 article (08/2001)
2.	Bilik, P: 1 article (08/2001)
3.	Boykin, D W: 1 article (08/2001)
4.	Colson, P: 1 article (08/2001)
5.	Facompré, M: 1 article (08/2001)
6.	Houssier, C: 1 article (08/2001)
7.	Kumar, A: 1 article (08/2001)
8.	Tanious, F: 1 article (08/2001)
9.	Tardy, C: 1 article (08/2001)
10.	Wilson, W D: 1 article (08/2001)

Related Diseases

1.	Leukemia 08/03/2001 - "The substitution of N-alkylamidines for the imidazoline terminal groups abolished the capacity of the drug to poison topoisomerase II. At the cellular level, flow cytometry analysis indicated that DB358, which is about six times more cytotoxic than the trifuran analogue, induced a significant accumulation of HL-60 human leukemia cells in the G2/M phase. "

Related Drugs and Biologics

1.	Imidazolines
2.	Poisons
3.	Type II DNA Topoisomerases (Topoisomerase II)