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inositol-1,3,4,5,6-pentakisphosphate

involved in signal transduction

Also Known As:

Ins(1,3,4,5,6)P5

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Sugar Alcohols: 143
    - Inositol: 2982
      - Inositol Phosphates: 351
        inositol-1,3,4,5,6-pentakisphosphate: 3
Carbohydrates: 22023
- Sugar Alcohols: 143
  - Inositol: 2982
    - Inositol Phosphates: 351
      - inositol-1,3,4,5,6-pentakisphosphate: 3
- Sugar Phosphates: 20
  - Inositol Phosphates: 351
    - inositol-1,3,4,5,6-pentakisphosphate: 3

Experts

1.	Broggini, Massimo: 2 articles (09/2005 - 03/2004)
2.	Falasca, Marco: 2 articles (09/2005 - 03/2004)
3.	Iacobelli, Stefano: 2 articles (09/2005 - 03/2004)
4.	Innocenti, Paolo: 2 articles (09/2005 - 03/2004)
5.	Maffucci, Tania: 2 articles (09/2005 - 03/2004)
6.	Piccolo, Enza: 2 articles (09/2005 - 03/2004)
7.	Potter, Barry V L: 2 articles (09/2005 - 03/2004)
8.	Riley, Andrew M: 2 articles (09/2005 - 03/2004)
9.	Cumashi, Albana: 1 article (09/2005)
10.	Godage, H Yasmin: 1 article (09/2005)

Related Diseases

1.	Neuroblastoma 05/15/1991 - "The potential Ca2(+)-releasing activity of the inositol tetrakisphosphates Ins(1,3,4,6)P4 and DL-Ins(1,4,5,6)P4 and the inositol pentakisphosphate Ins(1,3,4,5,6)P5 and their effect on Ins(1,4,5)P3- and DL-Ins (1,3,4,5)P4-mediated Ca2+ release were examined in permeabilized SH-SY5Y human neuroblastoma cells. "
2.	Neoplasms (Cancer) 03/04/2004 - "These results support a role for Ins(1,3,4,5,6)P5 as a specific inhibitor of the PI 3-K/Akt signalling pathway, that may sensitize cancer cells to the action of commonly used anticancer drugs."
3.	Lung Neoplasms (Lung Cancer) 03/04/2004 - "Furthermore, Ins(1,3,4,5,6)P5 enhances the proapoptotic effect of cisplatin and etoposide in ovarian and lung cancer cells, respectively. "
4.	Carcinoma (Carcinomatosis) 09/15/2005 - "In addition, the effect of Ins(1,3,4,5,6)P5 on growth of ovarian carcinoma SKOV-3 xenograft was tested. "
5.	Breast Neoplasms (Breast Cancer) 03/04/2004 - "As a consequence of this inhibition, Ins(1,3,4,5,6)P5 induces apoptosis in ovarian, lung and breast cancer cells. "

Related Drugs and Biologics

1.	Inositol (Myoinositol)
2.	Etoposide (VP 16)
3.	Cisplatin (Platino)
4.	inositol pentaphosphate (inositol pentakisphosphate)