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oleanonic acid

structure in first source

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - oleanonic acid: 7

Experts

1.	Cao, Shuying: 1 article (01/2022)
2.	Fang, Wenqing: 1 article (01/2022)
3.	Huang, Jin: 1 article (01/2022)
4.	Li, Weihua: 1 article (01/2022)
5.	Liu, Guixia: 1 article (01/2022)
6.	Liu, Zehui: 1 article (01/2022)
7.	Ma, Hui: 1 article (01/2022)
8.	Tang, Yun: 1 article (01/2022)
9.	Wu, Lili: 1 article (01/2022)
10.	Wu, Zengrui: 1 article (01/2022)

Related Diseases

1.	Cardiomegaly (Heart Hypertrophy) 01/01/2018 - "In vivo, similar results were observed in abdominal aortic constriction (AAC) rats that were intragastrically administered with oleanonic acid, and the pathological changes accompanying cardiac hypertrophy were relieved. " 01/01/2018 - "Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway." 01/01/2018 - "In conclusion, oleanonic acid can effectively ameliorate cardiac hypertrophy by inhibiting PKCζ-NF-κB signaling pathway."
2.	Neoplasms (Cancer) 01/01/2017 - "A total of 41 new triterpenoids were prepared from allobetulone, methyl betulonate, methyl oleanonate, and oleanonic acid to study their influence on cancer cells. " 05/01/2005 - "Oleanonic acid (3) and ursolonic acid (4) were found to be cytotoxic against a series of human cancer cell lines with IC50=4.6, 15.5 microM on MCF7; 4.2, 14.5 microM on K562; 14.8, 44.4 microM on Bowes; 24.9, 43.6 microM on T24S; 61.3, 151.5 microM on A549, respectively. "
3.	Ulcer 04/01/2002 - "The effect of OA, its acetylated and methoxylated derivatives, oleanonic acid and its methyl ester were assessed on HCI/ethanol-induced ulcers in mice at 200 mg kg(-1). "
4.	Multiple Sclerosis 01/26/2022 - "Moreover, the direct contact between ursonic acid and RORγt was confirmed using the X-ray crystal structure, and in vivo experiments demonstrated that ursonic acid and oleanonic acid have therapeutic effects on multiple sclerosis. "
5.	Human Influenza (Influenza) 12/02/2022 - "Synthesis, Anti-Influenza H1N1 and Anti-Dengue Activity of A-Ring Modified Oleanonic Acid Polyamine Derivatives." 12/02/2022 - "A series of sixteen A-ring modified (2,3-indolo-, 2-benzylidene) oleanonic acid derivatives, holding some cyclic amines, linear polyamines and benzylaminocarboxamides at C28, has been synthesized and screened for antiviral activity against influenza A/PuertoRico/8/34 (H1N1) and Dengue virus serotypes of DENV-1, -2, -3, -4. It was found that 28-homopiperazine 2 and 3-N-phthalyl 22 amides of oleanonic acid demonstrated high potency with selectivity index SI 27 (IC50 21 μM) and 42 (IC50 12 μM). "

Related Drugs and Biologics

1.	Triterpenes
2.	Phospholipases A2 (Phospholipase A2)
3.	Therapeutic Uses
4.	Leukotrienes
5.	Polyamines
6.	Esters
7.	Bradykinin
8.	Antiviral Agents (Antivirals)
9.	Amines
10.	Amides