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5-Fluoroindole-3-acetic acid

structure in first source

Also Known As:

5-FI-AA

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indoleacetic Acids: 615
        5-Fluoroindole-3-acetic acid: 2
- Heterocyclic Acids
  - Indoleacetic Acids: 615
    - 5-Fluoroindole-3-acetic acid: 2

Experts

1.	Folkes, Lisa K: 2 articles (06/2002 - 01/2002)
2.	Wardman, Peter: 2 articles (06/2002 - 01/2002)
3.	Rossiter, Sharon: 1 article (06/2002)
4.	Dachs, Gabi U: 1 article (01/2002)
5.	Greco, Olga: 1 article (01/2002)
6.	Stratford, Michael R L: 1 article (01/2002)

Related Diseases

1.

Neoplasms (Cancer)

01/15/2002 - "5-Fluoroindole-3-acetic acid: a prodrug activated by a peroxidase with potential for use in targeted cancer therapy."
01/15/2002 - "The high cytotoxicity of 5-fluoroindole-3-acetic acid after oxidative activation suggests its further evaluation as a prodrug for targeted cancer therapy involving antibody-, polymer-, or gene-directed delivery of horseradish peroxidase or similar activating enzymes."
06/01/2002 - "The results show that the cytotoxic response in the prodrug (indole acetic acid) and enzyme (horseradish peroxidase) system reflects the reactivity of methylene oxindoles toward nucleophiles much more than the rate of generation of the oxindoles, and helps explain the possible advantages of 5-fluoroindole-3-acetic acid compared to IAA as a lead compound for investigation in targeted cancer therapy."

Related Drugs and Biologics

1.	Prodrugs
2.	Horseradish Peroxidase
3.	Enzymes
4.	Polymers
5.	Peroxidase (Myeloperoxidase)
6.	Oxindoles
7.	indoleacetic acid (indole acetic acid)

Related Therapies and Procedures

1.	Therapeutics