glycogen synthase kinase 3 alpha

an isoform of glycogen synthase kinase 3

Also Known As:

GSK-3alpha; kinase F(A); protein kinase F(A); protein phosphatase activator FA

Networked: 24 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Axin Signaling Complex: 10
    - Glycogen Synthase Kinase 3: 810
      - glycogen synthase kinase 3 alpha: 24
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Glycogen Synthase Kinases: 841
        Glycogen Synthase Kinase 3: 810
        glycogen synthase kinase 3 alpha: 24
        Proline-Directed Protein Kinases: 28
        Glycogen Synthase Kinase 3: 810
        glycogen synthase kinase 3 alpha: 24
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Glycogen Synthase Kinases: 841
        Glycogen Synthase Kinase 3: 810
        glycogen synthase kinase 3 alpha: 24
      - Proline-Directed Protein Kinases: 28
        Glycogen Synthase Kinase 3: 810
        glycogen synthase kinase 3 alpha: 24
    - Axin Signaling Complex: 10
      - Glycogen Synthase Kinase 3: 810
        glycogen synthase kinase 3 alpha: 24

Experts

1.	Doble, Bradley W: 3 articles (11/2009 - 10/2007)
2.	MacAulay, Katrina: 3 articles (11/2009 - 10/2007)
3.	Woodgett, James R: 3 articles (11/2009 - 10/2007)
4.	Phiel, Christopher J: 2 articles (03/2010 - 05/2003)
5.	Gao, Shumin: 2 articles (12/2008 - 11/2007)
6.	Sadoshima, Junichi: 2 articles (12/2008 - 11/2007)
7.	Zhai, Peiyong: 2 articles (12/2008 - 11/2007)
8.	Drucker, Daniel J: 2 articles (10/2008 - 10/2007)
9.	Patel, Satish: 2 articles (10/2008 - 10/2007)
10.	Sinclair, Elaine M: 2 articles (10/2008 - 10/2007)

Related Diseases

1.	Insulin Resistance 11/19/2009 - "Mice lacking a functional GSK-3alpha gene were engineered in our laboratory; they are viable and display insulin sensitivity. " 08/01/2007 - "Compared with controls (CONT), HL increased insulin sensitivity, as assessed by hyperinsulinemic-euglycemic clamp ( approximately 15%), and increased SkM Akt ( approximately 30%) and glycogen synthase kinase 3 alpha ( approximately 52%) phosphorylation. " 10/01/2008 - "Mice engineered to lack GSK-3beta die in late embryogenesis from liver apoptosis, whereas mice engineered to lack GSK-3alpha are viable and exhibit improved insulin sensitivity and hepatic glucose homeostasis. " 10/01/2007 - "Unlike GSK-3beta mutants, which die before birth, GSK-3alpha knockout (GSK-3alpha KO) animals are viable but display enhanced glucose and insulin sensitivity accompanied by reduced fat mass. "
2.	Cognitive Dysfunction 06/01/2009 - "In this study, we measured GSK-3alpha and -3beta by quantitative ELISA in peripheral blood mononuclear cells of patients with mild cognitive impairment (MCI), AD and depression in comparison to healthy subjects. "
3.	Hypertrophic Cicatrix (Hypertrophic Scar) 11/01/2020 - "In this study, tissue microarray was used to evaluate the protein expression profile for Wnt3a, phosphorylated glycogen synthase kinase 3 alpha (pGSK-3α), WNT1-inducible-signaling pathway protein 1 (WISP1), and WISP2 in normal skin, scars, hypertrophic scars, and keloids. "
4.	Keloid 11/01/2020 - "In this study, tissue microarray was used to evaluate the protein expression profile for Wnt3a, phosphorylated glycogen synthase kinase 3 alpha (pGSK-3α), WNT1-inducible-signaling pathway protein 1 (WISP1), and WISP2 in normal skin, scars, hypertrophic scars, and keloids. "
5.	Cicatrix (Scar) 11/01/2020 - "In this study, tissue microarray was used to evaluate the protein expression profile for Wnt3a, phosphorylated glycogen synthase kinase 3 alpha (pGSK-3α), WNT1-inducible-signaling pathway protein 1 (WISP1), and WISP2 in normal skin, scars, hypertrophic scars, and keloids. "

Related Drugs and Biologics

1.	Glycogen Synthase Kinase 3 beta
2.	Glucose (Dextrose)
3.	Proteins (Proteins, Gene)
4.	Protein Isoforms (Isoforms)
5.	Glycogen Synthase Kinase 3
6.	Glycogen Synthase (Synthase I)
7.	Cyclin D1
8.	Protein Kinases (Protein Kinase)
9.	Caspase 3 (Caspase-3)
10.	Catenins