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SU(VAR)3-9

a histone methyltransferase, modifier of position effect variegation and interact genetically in flies

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - One-Carbon Group Transferases
      - Methyltransferases: 5778
        SU(VAR)3-9: 14

Experts

1.	Rubio-Tomás, Teresa: 2 articles (11/2021 - 06/2021)
2.	Baum, Thomas J: 1 article (01/2022)
3.	Bennett, Morgan: 1 article (01/2022)
4.	Hewezi, Tarek: 1 article (01/2022)
5.	Piya, Sarbottam: 1 article (01/2022)
6.	Che, Nan: 1 article (01/2021)
7.	Feng, Ying: 1 article (01/2021)
8.	Li, Chao: 1 article (01/2021)
9.	Xuan, Yanhua: 1 article (01/2021)
10.	Yang, Zhaoting: 1 article (01/2021)

Related Diseases

1.	Infections 01/01/2023 - "In this study, we identified a su(var)3-9, enhancer of zeste, and trithorax (SET) domain protein-encoding gene, PsKMT3, that was highly induced at early infection stages in Phytophthora sojae. " 01/01/2022 - "Here, we show how Arabidopsis (Arabidopsis thaliana) miR778 coordinately modulates the root transcriptome, histone methylation, and DNA methylation via post-transcriptional regulation of the H3K9 methyltransferases SU(var)3-9 homolog 5 (SUVH5) and SUVH6 upon infection by the beet cyst nematode Heterodera schachtii. "
2.	Neoplasms (Cancer) 01/01/2021 - "Su(var)3-9, Enhancer of Zeste, and Trithorax Domain-Containing 5 Facilitates Tumor Growth and Pulmonary Metastasis through Up-Regulation of AKT1 Signaling in Breast Cancer." 06/01/2021 - "The Su(Var)3-9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) proteins, named SMYD1, SMYD2, SMYD3, SMYD4 and SMYD5, are enzymes that catalyse methylation of histone and non-histone substrates, thereby playing a key role in gene expression regulation in many biological contexts, such as muscle development and physiology, haematopoiesis and many types of cancer. " 11/01/2021 - "The Su(Var)3-9, Enhancer-of-zeste and Trithorax (SET) and myeloid, Nervy, and DEAF-1 (MYND) domain-containing protein 2 (SMYD2) and 3 (SMYD3) are methyltransferases which act on histone and non-histone proteins to promote tumorigenesis in many cancer types. "
3.	Carcinogenesis 09/01/2006 - "Moreover, mutations in the genes encoding heterochromatin components heterochromatin protein 1 (HP1) and Su(var)3-9 enhance tumorigenesis induced by an oncogenic JAK kinase without affecting JAK/STAT signaling. " 11/01/2021 - "The Su(Var)3-9, Enhancer-of-zeste and Trithorax (SET) and myeloid, Nervy, and DEAF-1 (MYND) domain-containing protein 2 (SMYD2) and 3 (SMYD3) are methyltransferases which act on histone and non-histone proteins to promote tumorigenesis in many cancer types. "
4.	Sotos Syndrome 01/01/2020 - "Over 90% of Sotos syndrome patients are haploinsufficient for the gene encoding nuclear receptor-binding Su(var)3-9, Enhancer-of-zesteand Trithorax domain-containing protein 1 (NSD1). " 03/01/2008 - "Nuclear receptor-binding SET-domain-containing protein 1 (NSD1), a culprit gene for Sotos syndrome, contains a su(var)3-9, enhancer-of-zeste, trithorax (SET) domain that is responsible for histone methyltransferase activity and other domains such as plant homeodomain (PHD) and proline-tryptophan-tryptophan-proline (PWWP) involved in protein-protein interactions in the C-terminal half of NSD1. "
5.	Leukemia 08/15/1994 - "By molecular analysis, Su(var)3-9 could be correlated with a 2.4 kb transcript which encodes a putative protein of 635 amino acids containing a chromo domain and a region of homology to Enhancer of zeste and trithorax, two antagonistic regulators of the Antennapedia and Bithorax gene complexes, as well as to the human protein ALL-1/Hrx which is implicated in acute leukemias. " 08/01/2016 - "Upon androgen stimulation, AR recruits the Protein kinase N1 (PKN1), which phosphorylates histone H3 at threonine 11, with subsequent recruitment of tryptophan, aspartic acid (WD) repeat-containing protein 5 (WDR5) and the su(var)3-9, enhancer of zeste, trithorax/mixed-lineage leukemia (SET1/MLL) histone methyltransferase complex to promote AR target gene activation and prostate cancer cell growth. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Histones (Histone)
3.	Methyltransferases
4.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
5.	Histone Methyltransferases
6.	Tryptophan (L-Tryptophan)
7.	Threonine (L-Threonine)
8.	Messenger RNA (mRNA)
9.	Proline (L-Proline)
10.	Phosphotransferases (Kinase)