1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13)

structure in first source

Also Known As:

DOTA-(cysteinyl(3,4,10),D-phenylalanyl(7))alpha-MSH(3-13); DOTA-ReCCMSH

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Pituitary Hormones: 601
      - Anterior Pituitary Hormones: 187
        Pro-Opiomelanocortin: 1936
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
    - Hypothalamic Hormones: 68
      - Pro-Opiomelanocortin: 1936
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Melanocyte-Stimulating Hormones: 1119
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
      - Hypothalamic Hormones: 68
        Pro-Opiomelanocortin: 1936
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
- Peptides: 82426
  - Neuropeptides: 6772
    - Melanocyte-Stimulating Hormones: 1119
      - alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
    - Hypothalamic Hormones: 68
      - Pro-Opiomelanocortin: 1936
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
  - Peptide Hormones: 1347
    - Pituitary Hormones: 601
      - Anterior Pituitary Hormones: 187
        Pro-Opiomelanocortin: 1936
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
    - Hypothalamic Hormones: 68
      - Pro-Opiomelanocortin: 1936
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        alpha-MSH: 968
        1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1
Organic Chemicals: 133
- Organometallic Compounds: 64
  - 1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetic acid (Cys(3,4,10),D-Phe(7))alpha-MSH(3-13): 1

Experts

1.	Chen, J: 1 article (12/2001)
2.	Cheng, Z: 1 article (12/2001)
3.	Hoffman, T J: 1 article (12/2001)
4.	Jurisson, S S: 1 article (12/2001)
5.	Miao, Y: 1 article (12/2001)
6.	Owen, N K: 1 article (12/2001)
7.	Quinn, T P: 1 article (12/2001)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 12/01/2001 - "The novel ReO-coordinated cyclic structure of DOTA-ReCCMSH contributes significantly to its enhanced tumor-targeting and renal clearance properties and makes DOTAReCCMSH an excellent candidate for melanoma radiodetection and radiotherapy." 12/01/2001 - "The aim of this study was to examine the effect of rhenium-mediated peptide cyclization on melanoma targeting, biodistribution, and clearance kinetics of the alpha-melanocyte-stimulating hormone (alpha-MSH) analog 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) coupled ReO-cyclized [Cys(3,4,10),D-Phe(7)]alpha-MSH(3-13) (DOTA-ReCCMSH). "
2.	Neoplasms (Cancer) 12/01/2001 - "The novel ReO-coordinated cyclic structure of DOTA-ReCCMSH contributes significantly to its enhanced tumor-targeting and renal clearance properties and makes DOTAReCCMSH an excellent candidate for melanoma radiodetection and radiotherapy."

Related Drugs and Biologics

1.	Rhenium
2.	Peptides (Polypeptides)
3.	alpha-MSH
4.	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid

Related Therapies and Procedures

1.	Radiotherapy