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N- (1- (2,2- dimethyl- 1,3- dioxol- 4- yl)- 2- ((4,4- (trifluoromethoxyphenoxy)phenyl)sulfonyl)ethyl)- N- hydroxyformamide

structure in first source

Also Known As:

ABT-518; ABT518

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Formamides: 6
    - N-(1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-((4,4-(trifluoromethoxyphenoxy)phenyl)sulfonyl)ethyl)-N-hydroxyformamide: 5
- Carboxylic Acids: 973
  - Acyclic Acids
    - Formates: 7
      - Formamides: 6
        N-(1-(2,2-dimethyl-1,3-dioxol-4-yl)-2-((4,4-(trifluoromethoxyphenoxy)phenyl)sulfonyl)ethyl)-N-hydroxyformamide: 5

Experts

1.	Wada, Carol K: 2 articles (01/2004 - 01/2002)
2.	Bauters, D: 1 article (01/2012)
3.	Himmelreich, U: 1 article (01/2012)
4.	Kindt, N: 1 article (01/2012)
5.	Lijnen, H R: 1 article (01/2012)
6.	Noppen, B: 1 article (01/2012)
7.	Van Hul, M: 1 article (01/2012)
8.	Vanhove, M: 1 article (01/2012)
9.	Dagher, Pierre C: 1 article (01/2005)
10.	Kelly, K J: 1 article (01/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2004 - "ABT-518 is a potent, orally bioavailable, selective inhibitor of MMP-2 and 9 over MMP-1 that has been evaluated in Phase I clinical trials in cancer patients." 01/03/2002 - "Optimization of the substituent adjacent to the retrohydroxamate center in this series led to the clinical candidate ABT-518 (6), a highly potent, selective, orally bioavailable MMP inhibitor that has been shown to significantly inhibit tumor growth in animal cancer models." 03/01/2004 - "ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis. "
2.	Obesity 01/01/2012 - "1. The potential of the matrix metalloproteinase (MMP) inhibitor ABT-518 to affect pre-adipocyte differentiation in vitro and adipose tissue development in vivo was investigated using mouse models of adipogenesis and obesity. "
3.	Neoplasm Metastasis (Metastasis) 03/01/2004 - "ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis. "
4.	Ischemia 01/01/2005 - "ABT-518, a specific inhibitor of MMP-2 and MMP-9, also significantly reduced the extent of dextran (500 kDa) leakage from the renal microvasculature 24 h after ischemia. "

Related Drugs and Biologics

1.	Matrix Metalloproteinase Inhibitors
2.	Matrix Metalloproteinases (MMPs)
3.	Dextrans (Dextran)