polylysine-graft-(poly(ethylene glycol))

structure in first source

Also Known As:

PLL-g-PEG; poly-L-lysine-graft-(poly(ethylene glycol)); poly-L-lysine-graft-polyPEG

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Glycols: 38
    - Ethylene Glycols: 8
      - Polyethylene Glycols: 3865
        polylysine-graft-(poly(ethylene glycol)): 7
Macromolecular Substances: 97
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - polylysine-graft-(poly(ethylene glycol)): 7
Biomedical and Dental Materials
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - polylysine-graft-(poly(ethylene glycol)): 7
Technology, Industry, and Agriculture
- Manufactured Materials
  - Biomedical and Dental Materials
    - Polymers: 13051
      - Polyethylene Glycols: 3865
        polylysine-graft-(poly(ethylene glycol)): 7
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Polylysine: 237
    - polylysine-graft-(poly(ethylene glycol)): 7
- Amino Acids: 30675
  - Basic Amino Acids: 178
    - Lysine: 6737
      - Polylysine: 237
        polylysine-graft-(poly(ethylene glycol)): 7
  - Diamino Amino Acids: 101
    - Lysine: 6737
      - Polylysine: 237
        polylysine-graft-(poly(ethylene glycol)): 7

Experts

1.	Hubbell, Jeffrey A: 2 articles (09/2006 - 03/2002)
2.	Flynn, Nicholas: 1 article (10/2019)
3.	Ramsey, Joshua D: 1 article (10/2019)
4.	Ranjan, Ashish: 1 article (10/2019)
5.	Chen, Peilin: 1 article (09/2017)
6.	Fang, Ji-Tseng: 1 article (09/2017)
7.	Ho, Bo-Cheng: 1 article (09/2017)
8.	Hsiao, Yu-Sheng: 1 article (09/2017)
9.	Juang, Ruey-Shin: 1 article (09/2017)
10.	Kuo, Chiung-Wen: 1 article (09/2017)

Related Diseases

1.	Hyperplasia 09/01/2006 - "Polymeric steric stabilization of stents with PLL-g-PEG significantly reduces neointimal hyperplasia in the porcine restenosis model. " 09/01/2006 - "Neointimal hyperplasia was significantly less (-51%) in the PLL-g-PEG-coated stents (1.15 +/- 0.59 mm2) than in the uncoated control stents (2.33 +/- 1.01 mm2; p < 0.001). " 09/01/2006 - "The purpose of the present study was to investigate the effect of poly(L-lysine)-graft-poly(ethyleneglycol) (PLL-g-PEG) adsorbed to stent surfaces to reduce neointimal hyperplasia in the porcine restenosis model. "
2.	Capsule Opacification 03/15/2002 - "The PEG and PBA grafting ratios on these poly-L-lysine-graft-(PEG;PBA) copolymers [PLL-g-(PEG;PBA)] were varied, and the polymers were tested in models relevant to undesirable wound-healing responses such as peritoneal adhesion formation and posterior capsule opacification. "
3.	Wounds and Injuries (Trauma) 05/01/2013 - "Here we synthesized peptide-modified PLL-g-PEG polymers with two functionalities, characterized them in vitro and utilized them in vivo via a fibrin-based delivery matrix to induce dermal wound angiogenesis in diabetic rats. "
4.	Prostatic Neoplasms (Prostate Cancer) 10/01/2019 - "Here, complexes composed of the ROS enzyme glucose oxidase (GOX), poly-l-lysine-grafted-polyethylene glycol (PLL-g-PEG), and anti-prostate specific membrane antigen (anti-PSMA) monoclonal antibody are synthesized for localized delivery and uptake in prostate cancer cells. "
5.	Neoplasms (Cancer) 05/10/2013 - "Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy." 05/10/2013 - "In tumor-bearing mice, formulation of Photofrin with PLL-g-PEG enhanced tumor localization of Photofrin as twice as Photofrin alone and concomitantly suppressed the photosensitivity reaction drastically." 05/10/2013 - "To enhance localization of Photofrin to tumors, we have formulated Photofrin with the tumor-localizing graft copolymer poly(ethylene glycol)-grafted poly(l-lysine), PLL-g-PEG. "

Related Drugs and Biologics

1.	Lysine (L-Lysine)
2.	Ethylene Glycol (Monoethylene Glycol)
3.	Polymers
4.	Streptavidin
5.	Dihematoporphyrin Ether (Porfimer Sodium)
6.	Polyethylene Glycols (Polyethylene Glycol)
7.	Phosphates (Orthophosphate)
8.	Peptides (Polypeptides)
9.	Glucose Oxidase
10.	Fibrin

Related Therapies and Procedures

1.	Stents
2.	Photochemotherapy (Photodynamic Therapy)